ĐÁNH GIÁ SỰ ĐÁP ỨNG CỦA TEST KÍCH THÍCH THẦN KINH LẶP LẠI LIÊN TIẾP Ở BỆNH NHÂN NHƯỢC CƠ THỂ MẮT

Abstract

Aim: To evaluate the response of consecutively repeated nerve stimulation tests in patients with ocular myasthenia gravis. Objects and methods:  43 patients with ocular myasthenia gravis had positive anti-acetylcholine antibody or positive neostigmine test. Results: The average age of onset of patients was 39.2 ± 17.7 (ocular myasthenia gravis), 43.1 ± 13 (generalized myasthenia gravis), the time since the onset of ocular myasthenia gravis the conversion to the whole body was 18.9 ± 59.7 months. The repetitive nerve stimulation test was positive in 28 patients (65.1%), the positive rate in ocular myasthenia gravis 30.2%, sensitivity 30.8%, sensitivity 80% for the generalized myasthenia gravis group. The sensitivity of each muscle also varies according to muscle group: trapezius muscle (61.5%), ocular muscle (53.8%), abductor pollicis brevis (30.8%), abductor digiti minimi muscle (38.5%), and sensitivities of repetitive nerve stimulation were significantly higher in the generalized myasthenia gravis according to subgroup: 90%, 86.7%, 80%, 66.7%. Repetitive nerve stimulation is associated with clinical severity according to Osserman's classification (P = 0.001). Conclusions: Repetitive nerve stimulation test is a simple and convenient test that can help diagnose myasthenia gravis faster and can detect subclinical muscle weakness.