NGHIÊN CỨU MỐI LIÊN QUAN GIỮA NỒNG ĐỘ PESINOGEN HUYẾT THANH VỚI TỔN THƯƠNG NIÊM MẠC DẠ DÀY TRÊN MÔ BỆNH HỌC

Abstract

Material and methods: A cross-sectional study was conducted in DakLak from March 2015 to June 2018 with 130 patients at the age from 18 years and over who were histopathologically diagnosed with chronic gastritis. All patients underwent gastroscopy, biopsy for histopathological diagnosis, and serum pepsinogen I and II testing. Results: The mean level of PGI was 57.43 ± 34.36 ng/ml, PGII was 15.83 ± 8.31 ng/ml. The level of PGI in the group with intestinal metaplasia was 85.81 ± 71.34 ng/ml, which was higher than the group without intestinal metaplasia 55.07 ± 28.26 ng/ml with p < 0.001. The level of PGI and PG I/II tended to decrease according to the level of atrophic gastritis on histopathology, however, there was no statistically difference with p > 0.05. The level of PG I/II in the active inflammation group was 3.82 ± 1.32, inactive inflammation was 3.84 ± 1.37 and there was no statistically significant difference with P> 0.05. No statistical correlation was found between the level of active inflammation with age and gender. Conclusion: The mean level of PGI and PG I/II ratio tend to decrease inversely with the level of atrophic inflammation; PG I concentration in the group with intestinal metaplasia was higher than the group without intestinal metaplasia (P<0.01). There was no statistical association between active gastritis and PG I concentration and PG I/II ratio. The threshold for PG I/II ratio in patients with severe atrophy is 3.2 ± 0.71, higher than the Japanese PG I/II threshold of < 3.