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Ngày xuất bản: 29/11/2024
Số lượt xem tóm tắt: 101
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DOI: https://doi.org/10.51298/vmj.v544i2.11908
Số xuất bản
Tập 544 Số 2 (2024): Vietnam Medical Journal
Chuyên mục
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Phan , H. M., Ho , M. D., Tran , T. T. T., Tran , T. D., Nguyen , X. T., Bui , T. T., Pham , T. V. A., & Mai , P. T. (2024). IMMUNOSTIMULATORY EFFECT OF JASMINUM SUBTRIPLINERVE BLUME LEAVES EXTRACT ON CYCLOPHOSPHAMIDE-INDUCED IMMUNOSUPPRESSION IN MICE. Tạp Chí Y học Việt Nam, 544(2). https://doi.org/10.51298/vmj.v544i2.11908

IMMUNOSTIMULATORY EFFECT OF JASMINUM SUBTRIPLINERVE BLUME LEAVES EXTRACT ON CYCLOPHOSPHAMIDE-INDUCED IMMUNOSUPPRESSION IN MICE

Phan Hong Minh1, Ho My Dung1, Tran Thi Thu Trang2, Tran Tien Dat1, Nguyen Xuan Tuan1, Bui Thanh Tung1, Pham Thi Van Anh3, Mai Phuong Thanh3,
1 University of Medicine and Pharmacy, Vietnam National University Hanoi
2 Hanoi University of Pharmacy
3 Hanoi Medical University

Nội dung chính của bài viết

Tóm tắt

The objective of this study was to evaluate the immunostimulatory activity of Jasminum subtriplinerve Blume. extract (JM). We induced the immunosuppression in Swiss mice by cyclophosphamide (CP). Jasminum subtriplinerve Blume. extract 14.4 g/kg body weight was administered orally 7 consecutive days to animals and CP (200 mg/kg i.p.) was injected on 4th day. The result showed that Jasminum subtriplinerve Blume. leaves extract 14.4 g/kg ameliorated the effects of CP on delayed type hypersensitivity (DTH) response, leukocyte quantity, relative organ weight, IgM concentration and micro-histological images. This suggested the potential of Jasminum subtriplinerve Blume leaves extract to treat immunosuppression diseases in clinical practice.


 

Chi tiết bài viết

Từ khóa

Immunostimulatory activity, Immunosuppression, Swiss mice, Cyclophosphamide, Jasminum subtriplinerve Blume. leaves.

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