ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ NỒNG ĐỘ NITRIC OXIDE TRONG KHÍ THỞ RA Ở BỆNH NHÂN BỆNH PHỔI TẮC NGHẼN MẠN TÍNH

Abstract

Objectives: To evaluate Fractional Exhaled Nitric Oxide (FeNO) and some influencing factors in stable Chronic Obstructive Pulmonary Disease (COPD) patients. Subjects: Including 131 patients diagnosed with COPD according to GOLD 2021 managed at the Chronic Lung Disease Management Department of Bach Mai Hospital from 8/2021 to 8/2022, patients outside of acute exacerbation and tested for FeNO. Methods: Cross- sectional descriptive study. Result: The 131 patients studied had an average age of 70.30±8.79 years old; male/female ratio = 8/1; disease stage ratio according to GOLD 2021 were: GOLD A (0.8%), GOLD B (13%), GOLD C (6.9%), GOLD D (79.4%); Average FeNO was 16.08±10.07 ppb, the highest measured FeNO value was 70 ppb, the lowest was 2 ppb; Average FeNO in the group of patients with a history of allergies (42.44±12.38 ppb) was higher than in the group of patients without a history of allergies (14.14±6.58 ppb) with statistical significance at p<0.001. The mean FeNO in the group of patients treated with ICS (18.55±11.37 ppb) was higher than that in the group not treated with ICS (12.79±6.82 ppb) with statistical significance at p<0.05. There was no correlation between FeNO and the levels of dyspnea and the stages of GOLD. There was no correlation between FeNO and %FVC, %FEV1, %FEV1/FVC, eosinophil count in peripheral blood. Conclusion: There was a relationship between people with a history of allergies and ICS treatment and FeNO levels. There was no correlation between FeNO and the number of cigarettes smoked, %FVC, %FEV1, %FEV1/FVC, eosinophil count in peripheral blood.