Article Sidebar
Views pdf: 273
CLINICAL AND LABORATORY CHARACTERISTICS OF PERSISTENT DIARRHEA IN INFANTS OF MATERNAL COVID-19 PREGNANCIES
Main Article Content
Abstract
A comparative cross-sectional study was conducted at Vietnam National Children's Hospital from July 2022 to July 2023, involving 158 infants with prolonged diarrhea (62 born to mothers with COVID-19 during pregnancy and 96 controls). Multivariate analysis, after adjusting for confounding factors, revealed that infants born to mothers with COVID-19 during pregnancy had significantly higher risks of: mucous stools (aOR=2.2; 95% CI: 1.3-3.7; p=0.003), stool frequency ≥6 times/day (aOR=2.0; 95% CI: 1.2-3.3; p=0.009), and history of illness in the first two months (aOR=1.9; p=0.008). Other characteristics including type 5A/5B stools (aOR=1.8), bloody stools (aOR=1.7), anemia (aOR=1.7), and iron deficiency (aOR=1.8) also showed significantly higher risks (p<0.05). These findings suggest the existence of a pathological cycle, where gut microbiota dysbiosis and immune dysfunction due to maternal COVID-19 may lead to and maintain chronic inflammation in infants.
Article Details
Keywords
Maternal COVID-19, persistent diarrhea, gut microbiota, inflammation, micronutrients, infants.
References
2. Das JK, Padhani ZA, Bhutta ZA. Persistent Diarrhea in Children in Developing Countries. In: Guandalini S, Dhawan A, eds. Textbook of Pediatric Gastroenterology, Hepatology and Nutrition. Springer; 2022:231-240.
3. Leftwich HK, Morris BM, Prater KN, et al. The microbiota of pregnant women with SARS-CoV-2 and their infants. Microbiome. 2023;11(1):141.
4. Jácome Á, Castañeda-Orjuela C, Barahona N. Indirect effects of the SARS CoV-2 pandemic on breastfeeding prevalence. Biomédica. 2021;41(Sp2):118-129.
5. Vu NT, Le VP, Le HC, et al. Etiology and epidemiology of diarrhea in children in Hanoi, Vietnam. Int J Infect Dis. 2006;10:298-308.
6. Nguyễn TC, Phạm VPT, Lê TMA, Nguyễn TDC, Đào TTC, Trương TPN. Nghiên cứu một số yếu tố nguy cơ tiêu chảy kéo dài ở trẻ em. Tạp chí Nhi Khoa. 2023;16(2):15-22.
7. Bogaert D, van Beveren GJ, de Koff EM, et al. Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites. Cell Host Microbe. 2023;31(3):447-460.
8. Kloc M, Ghobrial RM, Kuchar E, Lewicki S, Kubiak JZ. Development of child immunity in the context of COVID-19 pandemic. Clin Immunol. 2020;217:108510.
9. Sturrock S, Ali S, Gale C, Battersby C, Le Doare K. Neonatal outcomes and indirect consequences following maternal SARS-CoV-2 infection in pregnancy: a systematic review. BMJ Open. 2023;13(3):e063052.
10. Matyas M, Valeanu M, Hasmasanu M, et al. The Effect of Maternal SARS-CoV-2 Infection on Neonatal Outcome. Children. 2023;10(5):771.