THE CHANGES IN A PERIPHERAL BLOOD MONONUCLEAR CELL CONCENTRATIONS FROM MOTHER AND CORD BLOOD OF PREGNANT WOMEN INFECTED WITH HBsAg (+)
Main Article Content
Abstract
HBV-infected monocytes can act as vectors of HBV transmission from mother to fetus. Objective: To find out the changes in mononuclear white cell concentration in maternal and umbilical cord blood in pregnant women infected with HBsAg (+). Subjects: 60 pregnant women carrying one live, full-term fetus to give birth at Thai Nguyen Central Hospital with HBsAg (+) and umbilical cord blood immediately after birth. Research design: Descriptive, cross-sectional. Results: Mean age 27.6 ± 4.2 years. Maternal blood mononuclear cells ≥8x106 (cells/mL) accounted for 21.6%; Cord blood mononuclear cells ≥6.6 x106 (cells/mL) accounted for 46.7%. High maternal blood mononuclear cell group & low HBV DNA in maternal blood increase the number of cord blood mononuclear cells, and low maternal blood mononuclear cell group & high HBV DNA in maternal blood were found to decrease umbilical cord blood mononuclear cell concentration.
Article Details
Keywords
Peripheral Blood Mononuclear Cell, HBV DNA, Cord blood
References

2. Eke Christopher, Onyire Nnamdi, Amadi O. F. (2016), "Prevention of mother to child transmission of hepatitis B virus infection in Nigeria: A call to action", Nigerian Journal of Paediatrics, 43 pp. 201.

3. Joshi S. S., Coffin C. S. (2018), "Hepatitis B virus lymphotropism: emerging details and challenges", Biotechnol Genet Eng Rev, 34 (1), pp. 139-51.

4. Mavilia M. G., Wu G. Y. (2017), "Mechanisms and Prevention of Vertical Transmission in Chronic Viral Hepatitis", J Clin Transl Hepatol, 5 (2), pp. 119-29.

5. Nguyen V. T., Law M. G., Dore G. J. (2008), "An enormous hepatitis B virus-related liver disease burden projected in Vietnam by 2025", Liver Int, 28 (4), pp. 525-31.

6. Shi X., Wang X., et al. (2017), "Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission", Front Med, 11 (4), pp. 548-53.

7. Wang D. D., Yi L. Z., et al. (2019), "Relationship between Maternal PBMC HBV cccDNA and HBV Serological Markers and its Effect on HBV Intrauterine Transmission", Biomed Environ Sci, 32 (5), pp. 315-23.

8. Wen W. H., Huang C. W., et al. (2016), "Quantitative maternal hepatitis B surface antigen predicts maternally transmitted hepatitis B virus infection", Hepatology, 64 (5), pp. 1451-61.

9. Xu Y. Y., Liu H. H., et al. (2015), "Peripheral blood mononuclear cell traffic plays a crucial role in mother-to-infant transmission of hepatitis B virus", Int J Biol Sci, 11 (3), pp. 266-73.
