LIỆU PHÁP HOÁ DƯỢC TRONG ĐIỀU TRỊ PHA CẤP TÍNH Ở BỆNH NHÂN RỐI LOẠN TRẦM CẢM TÁI DIỄN

Abstract

Currently, there are many methods applied in the acute phase treatment of a depressive episode. Pharmacotherapy, especially selective serotonin reuptake inhibitors antidepressants, remains the most frequent option for treating depression during the acute phase. The study was conducted on 109 patients diagnosed with recurrent depressive disorder according to the ICD-10 (1992) criteria, who were hospitalized at the Institute of Mental Health - Bach Mai Hospital from January 2020 to December 2021. The study used a cross-sectional descriptive research method. The results obtained: the proportion of female patients was 72.48%; the majority of patients had experienced two episodes of depression by the time of hospitalization (56.88%). Among the pharmacological treatment method recorded, the combination of antidepressants with antipsychotics and anxiolytics was the most common (91.74%). 100% of patients with recurrent depression were prescribed antidepressants, with Sertraline being the most frequently used. Mood stabilizers were rarely used clinically (2.75%). No patients in the study were using stimulant medications. HAM-D scores decreased gradually from the time of admission, after 2 weeks of treatment and after 4 weeks of treatment. It can be said that the pharmacological intervention in the study group is consistent with major treatment guidelines in Vietnam and around the world.