THE CLINICAL EFFECTS OF ADVANCED PLATELET-RICH FIBRIN COMBINED WITH XENOGENIC BONE IN PERIODONTAL TREATMENT
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Abstract
Purpose: Periodontitis is a common oral disease and the leading cause of tooth loss. The aim of the study is to evaluate the clinical effects of advanced platelet-rich fibrin (A-PRF) and xenogenic bone substitute material (XBSM) in periodontal treatment. Materials and methods: 46 intrabony defects of 23 patients were randomly divided into 2 groups: test group (A-PRF-XBSM + collagen membrane + PRF membrane) and control group (XBSM + collagen membrane). The following clinical parameters were recorded at baseline (T0) and 3 months (T3) after surgery: plaque index (PlI), gingival index (GI), gingival recession (GR) pocket depth (PD) and clinical attachment level (CAL). Result: Significantly greater mean reduction of PD and CAL gain was observed in test group in comparison with control group at 3 months (p < 0,05). Conclusion: The use of advanced platelet-rich fibrin and xenogenic bone improved periodontal pocket depth and clinical attachment loss, might provide potential advantages for periodontal tissue regeneration.
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Keywords
periodontitis, periodontitis, platelet-rich fibrin, xenogenic bone, clinical effects
References

2. Miron R. J., Moraschini V., Fujioka-Kobayashi M., et al. (2021), “Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis”, Clin Oral Investig, 25(5), pp. 2461-2478.

3. Pepelassi E., Deligianni M., (2022), “The adjunctive use of leukocyte and platelet rich fibrin in periodontal endosseous and furcation defects: A systematic review and meta-analysis”, Materials (Basel), 15(6), pp. 2088.

4. Lekovic V., Milinkovic I., Aleksic Z., et al. (2011), “Platelet rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects”, J Periodontal Res, 47(4), pp. 409-417.

5. Reynold A. M., Reidy A. M., Branch-May L. G., et al. (2003), “The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review”, Ann Periodontol, 8, pp. 227-265

6. Juneja G., Bharti V., (2015), “Treatment of periodontal intrabony defects with platelet rich fibrin and porous hydroxyapatite bone graft: A comparative clinical and radiographic study using Dentascan”, Saint Int Dent J, (1), pp. 22-27.

7. Agarwal A., Gupta N. D., Jain A., et al. (2016), “Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trial”, Acta Odontol Scand, 74(1), pp. 36-43.

8. Elgendy A., Shady A., et al. (2015), “Clinical and radiographic evaluation of nanocrystalline hydroxyapatite with or without platelet-rich fibrin membrane in the treatment of periodontal intrabony defects”, J Indian Soc Periodontol, 19(1), pp. 61-68.
