KHẢO SÁT NỒNG ĐỘ CRP VÀ MỐI LIÊN QUAN GIỮA CRP VỚI MỘT SỐ XÉT NGHIỆM TRÊN BỆNH NHÂN HIV/AIDS

Abstract

Background: HIV/AIDS is a progressive infectious disease characterized by a decline in immune function, presenting significant challenges for public health systems. Since 2020, the incidence of HIV/AIDS has shown an increasing trend. As of October 2022, Vietnam reported 220,580 individuals living with HIV, with 112,380 deaths attributed to the disease. The prevalence is particularly high among men who have sex with men (MSM), with sexual transmission identified as the primary mode of infection. Methods: This study aimed to assess the levels of C-reactive protein (CRP) in HIV-positive patients and to investigate its correlation with various biochemical parameters. A cross-sectional study was conducted from June 2023 to June 2024 at Bach Mai Hospital and Hospital 09, involving 90 HIV/AIDS patients and 40 healthy controls. CRP and Ferritin levels, along with several hematological and biochemical markers, were analyzed using appropriate statistical methods. The results revealed an average CRP level of 7.15 mg/L in the HIV/AIDS group, significantly higher than the control group’s 1.502 mg/L (p>0.05). The average Ferritin level in HIV/AIDS patients was 457.2 ng/mL, substantially elevated compared to the control group’s 192.95 ng/mL (p<0.001). Additionally, a correlation was noted between Ferritin and several hematological parameters, whereas CRP exhibited a weak correlation with leukocyte counts. In conclusion, while CRP levels were elevated in HIV/AIDS patients, the differences compared to controls were not statistically significant. In contrast, Ferritin levels were significantly higher in the HIV group and correlated with critical hematological parameters, indicating its potential role in monitoring the clinical status of these patients. Future studies with larger sample sizes are warranted to further elucidate the implications of Ferritin in HIV/AIDS management.