TÍNH KHÁNG KHÁNG SINH CỦA CĂN NGUYÊN VI KHUẨN GÂY NHIỄM KHUẨN HUYẾT SƠ SINH TẠI BỆNH VIỆN PHỤ SẢN TRUNG ƯƠNG

Abstract

Objective: This study aims to evaluate the antibiotic resistance of bacterial pathogens causing neonatal sepsis at the Neonatal Center, National Hospital of Obstetrics and Gynecology. Subjects and Methods: A case series study was conducted on 65 neonates diagnosed with neonatal sepsis who had positive blood cultures for bacteria during the period from May 2024 to January 2025. Results: The rates of early-onset and late-onset neonatal sepsis were 29,2% and 70,8%, respectively. The most common Gram-negative bacteria causing neonatal sepsis were E. coli and K. pneumoniae. The most common Gram-positive bacteria were S. aureus and S. agalactiae. No Gram-positive bacterial strains isolated were resistant to vancomycin, linezolid, or tigecycline. Over 60% of K. pneumoniae strains were resistant to carbapenem, while this resistance rate was below 10% among E. coli strains. Conclusion: The rate of late-onset neonatal sepsis was higher than that of early-onset neonatal sepsis. E. coli and K. pneumoniae were the most common pathogens causing neonatal sepsis. The resistance rate of K. pneumoniae to carbapenem is relatively high.