CHANGES IN SALIVARY MALONDIALDEHYDE LEVELS AFTER THE EXTRACTION OF ASYMPTOMATIC IMPACTED MANDIBULAR THIRD MOLARS

Lý Nguyễn Thị Bích, Diêm Vũ Trọng, Nam Huỳnh Công Nhật

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Abstract

Introduction: Malondialdehyde (MDA) is the main product of the lipid peroxidation process and has significant values in the diagnosis and follow-up progression of several oral diseases. In our previous study, we investigated the levels of MDA in the dental follicle, gingival tissue, and saliva of patients with a single asymptomatic impacted mandibular third molar (IMTM). This present study aims to measure and evaluate MDA level change in saliva after extraction on patients with an IMTM and compare salivary MDA concentration in patients with MITM with a healthy control, then determine whether saliva is a good means of assessing the level of oxidative biomarker. Material and method: A total of 48 subjects were divided into two groups: patients with a single asymptomatic IMTM and volunteers without impacted teeth. All people were collected saliva (before extraction in the study group). One month after extraction, in the study group, saliva samples were collected to evaluate the difference in oxidative stress. Results: Patients with asymptomatic MITMs manifested MDA concentration higher than healthy control subjects with statistical significance (p<0,05). One month after extraction, salivary MDA decreased considerably in the study group (p<0,05), with no difference compared to volunteers without impacted teeth. Conclusions: Salivary MDA concentrations are higher among patients with one asymptomatic MITM, but these levels decrease significantly one month after tooth removal. The large reduction in oxidative stress biomarker could recommend third molar extraction despite the absence of symptoms.

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References

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