KHẢO SÁT NỒNG ĐỘ IGF-1 HUYẾT TƯƠNG VÀ MỘT SỐ YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN BỆNH THẬN MẠN GIAI ĐOẠN CUỐI ĐANG LỌC MÁU CHU KỲ

Abstract

Background: insulin-like growth factor 1 (IGF-1), also known as somatomedin C, is a hormone structurally similar to insulin, secreted by the liver in response to growth hormone (GH) produced by the pituitary gland. IGF-1 plays a crucial role in the structural and functional development of cells in the body. In patients with end-stage renal disease, especially those undergoing hemodialysis, IGF-1 levels are often disrupted, contributing to many serious complications such as malnutrition, chronic inflammation, and metabolic disorders. Objectives: to investigate plasma IGF-1 levels and the relationship between plasma IGF-1 levels and certain factors in end-stage renal disease patients undergoing hemodialysis. Materials and methods: a cross-sectional descriptive study with a random sample of 158 end-stage renal disease patients undergoing hemodialysis at Can Tho City General Hospital from August 2023 to January 2025. Results: the average patient age was 54.1 ± 13.4, males accounted for 44.3%, the average BMI was 19.21 ± 1.28 kg/m2, the average disease duration was 75.26 ± 23.9 months, and the average dialysis duration was 69.41 ± 23.8 months. The plasma IGF-1 concentration was 116.1 ng/ml, the highest concentration was 361.7 ng/ml, and the lowest concentration was 30.5 ng/ml. There was a correlation between plasma IGF-1 levels and several factors: BMI (OR=5.27 (2.25-12.345), p <0.001), blood albumin levels (OR=10.768(4.495-25.794), p <0.001), and blood PTH levels (OR=4.172 (0.985-17.68), p=0.038), and no correlation with dialysis duration (OR=1.375 (0.629-3.005), p=0.423) and the inflammatory factor CRPhs in the body (OR=1.16 (0.538-2.5), p=0.705). Conclusion: the decrease in plasma IGF-1 levels is associated with nutritional status (BMI and serum albumin) and PTH levels.