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EFFECTS OF ENDOMETRIAL THICKNESS AND THE RESULTS IN PATIENTS USING AUTOLOGICAL PLATELET-RICH PLASMA IN FROZEN EMBRYO TRANSFER
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Abstract
The use of autologous platelet-rich plasma (PRP) has emerged as an optimal method for patients with thin endometrium, showing high efficacy as previously tested in multiple in vitro fertilization (IVF) centers both domestically and internationally. Objective: This study aims to evaluate the effect of autologous PRP on endometrial thickness and pregnancy outcomes in patients with thin endometrium undergoing frozen embryo transfer. Methodology: Eligible patients underwent transvaginal ultrasound on day 2 or 3 of their menstrual cycle to assess endometrial thickness. An appropriate dosage of exogenous hormones was administered to prepare the endometrium based on ovarian stimulation characteristics or previous cycle data. Autologous PRP was then injected into the uterine cavity once or twice starting on day 10 of the cycle, with endometrial thickness reassessed 48 to 72 hours after each PRP administration. The primary outcome was the change in endometrial thickness after PRP injection, while secondary outcomes included the rate of positive beta-hCG, clinical pregnancy rate, ongoing pregnancy rate, miscarriage rate, biochemical pregnancy rate, and pregnancy loss rate 14 days post-embryo transfer. Results: After PRP administration, endometrial thickness showed a statistically significant increase of 1.31mm (p < 0.001, 95% CI: 0.79 - 1.84) compared to pre-PRP thickness. No significant difference in endometrial thickness was observed between the first and second PRP administrations, with an average increase of 0.31mm (p = 0.657). Among 35 patients, the positive beta-hCG rate was 54.3%, the clinical pregnancy rate was 46.7%, and the ongoing pregnancy rate was 43.5%. Conclusion: Autologous PRP is highly effective in increasing endometrial thickness and improving pregnancy outcomes in frozen embryo transfer cycles with endometrial preparation by PRP.
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Keywords
Thin endometrium, platelet-rich plasma, Frozen embryo transfer, the rate of ongoing pregnancy
References
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