CORRELATION BETWEEN NT-PROBNP AND ECHOCARDIOGRAPHIC PARAMETERS IN PATIENTS WITH ARRHYTHMIAS

Tóm tắt

Background: Arrhythmias are a significant public health burden, associated with increased morbidity and mortality. NT-proBNP, a biomarker of cardiac stress, has been shown to be elevated in various cardiovascular conditions. Objective: This study aimed to determine NT-proBNP concentrations in a cohort of patients with arrhythmias and evaluate the correlation between echocardiographic indices such as EF, EDV, ESV, and left ventricular dimensions (LVEDD, LVESD) and NT-proBNP concentrations in this patient population. Subjects and Methods: This study included 272 patients with various types of arrhythmias. Echocardiographic parameters, including EF, EDV, ESV, LVEDD, and LVESD were obtained. NT-proBNP levels were measured in all patients. Spearman's rank correlation coefficient was used to assess the relationship between NT-proBNP and echocardiographic parameters. Multivariate regression analysis was performed to adjust for potential confounders. Results: The median NT-proBNP level was 44.1 pmol/L. 69.5% of patients had levels above 15 pmol/L. Patients with ventricular arrhythmias had higher median NT-proBNP levels compared to those with non-ventricular arrhythmias (94.6 vs. 42.3 pmol/L), although not statistically significant. Spearman's rank correlation analysis revealed a significant inverse correlation between NT-proBNP and EF. Furthermore, positive correlations were observed between NT-proBNP and LVESD and LVEDD. Multivariate regression analysis, adjusting for age, eGFR, and heart failure status, confirmed independent associations between NT-proBNP and EF, ESV, LVEDD and LVESD. Conclusions: Higher NT-proBNP levels were associated with reduced EF and increased left ventricular dimensions, even after adjusting for potential confounders. These findings suggest that NT-proBNP may be a useful biomarker for assessing cardiac function and identifying patients at higher risk for adverse outcomes in this population.