NỒNG ĐỘ HUYẾT THANH MỘT SỐ CYTOKINE (GM-CSF, IL-10, IL-12 VÀ IL-17A) TRONG BỆNH HỒNG BAN ĐA DẠNG LAN TỎA

Abstract

We conducted this study sectional descriptive to investigate serum concentrations of some cytokines: Granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-10, IL-12, and IL-17A in generalized erythema multiforme. It was conducted at the National Hospital of Dermatology and Venereology, in Hanoi, Vietnam, from April 2017 to August 2019. Serum GM-CSF, IL-10, IL-12, and IL-17A concentrations were quantified by using the fluorescence covalent microbead immunosorbent assay. The mean age of the EM patients was 42.2. There were 22 patients (66.7%) with illness duration of less than 1 week. There were 60.6% of patients with a history of using medicine before onset. Only 15.2% of patients had mucosal lesions. In the EM group, serum concentrations of GM-CSF, IL-12, and IL-17A were 5.43±13.22 pg/ml, 0.92±2.19 pg/ml, and 0.28±0.29 pg/ml, respectively, significantly lower than those in HCs group, with p<0,01. Serum levels of GM-CSF, IL-12, and IL-17A in the HCs group were 31.99±31.64 pg/ml, 5.47±4.5 pg/ml, and 1.46±2.18 pg/ml, respectively. The serum concentration of IL-10 in the EM group was 9.86±15.29 pg/ml, not different from that in the EM group (11.84±11.09 pg/ml). There was no correlation between serum levels of cytokines with age in the EM group.