NGHIÊN CỨU GEN CAGA CỦA HELICOBACTER PYLORI Ở BỆNH NHI BỆNH LÝ DẠ DÀY – TÁ TRÀNG TẠI BỆNH VIỆN NHI ĐỒNG CẦN THƠ

Abstract

Background: Helicobacter pylori (H. pylori) infection can be acquired during childhood and persistent infection with this bacterium as a potential root leading to several gastroduodenal diseases, including gastric cancer in adulthood. The virulence factor CagA, encoded by the CagA gene of H. pylori, is one of the factors considered when deciding on the eradication of H. pylori in children. Research objectives: Determine the prevalence of H. pylori with CagA gene; Analyze the relationship between CagA gene with lesions observed in esophagogastroduodenoscopy. Subjects and research methods: A cross-sectional descriptive research involving 85 children with gastroduodenal diseases aged 5 to 16 years at Can Tho Children's Hospital. Results: The prevalence of CagA gene-positive H. pylori in children with gastroduodenal diseases is 69.2%. Strains of H. pylori with the CagA gene are related to an increased risk for gastroduodenal ulcers (aOR = 4,059; 95% CI: 1,243-13,254; p=0.018). Conclusion: The prevalence of CagA gene-positive H. pylori strains is high. The CagA gene is related to an increased risk of gastroduodenal ulcers.