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CASE REPORT: GASTROINTESTINAL BLEEDING IN GASTRIC CANCER PATIENT TREATED WITH CAPECITABINE
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Abstract
Capecitabine is an oral prodrug of fluorouracil (FU), is used alone or in combination with other chemotherapy agents in the treatment of many cancers. Capecitabine in combination with oxaliplatin (XELOX) as a first-line therapy for advanced gastric cancer. There have been many reports of capecitabine-induced enterocolitis presenting as diarrhea. However, as capecitabine has become more widely used, severe adverse events have been reported, such as gastrointestinal haemorrhage, gastrointestinal ulceration, and gastrointestinal obstrution. Severe gastrointestinal bleeding caused by capecitabine is rare but potentially life-threatening, requiring early detection and timely intervention. We report the first case of severe gastrointestinal bleeding occurring at the Department of Oncology and Nuclear Medicine, Ha Tinh Provincial General Hospital in 5/2024-6/2024.. In the case of a 45-year-old male patient diagnosed with pT2N2M0 gastric cancer, treated with XELOX adjuvant chemotherapy, severe gastrointestinal bleeding occurred in the 4th chemotherapy cycle on day 17 of the cycle and the 5th chemotherapy cycle on day 12.
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Keywords
Capecitabine, gastrointestinal bleeding
References
2. Dean Laura and Kane Megan (2020), "Capecitabine therapy and DPYD genotype".
3. Gomez-Paz Sandra and et al (2022), "S2678 A Case of Capecitabine-Induced Gastrointestinal Hemorrhage", Official journal of the American College of Gastroenterology| ACG. 117(10S), pp. e1767.
4. Hagiwara Yuya and et al (2022), "Severe gastrointestinal disorder due to capecitabine associated with dihydropyrimidine dehydrogenase deficiency: a case report and literature review", Internal Medicine. 61(16), pp. 2449-2455.
5. Ikuno Nobuhiro, Soda Hiroshi, Watanabe Masami and Oka Mikio (1995), "Irinotecan (CPT-11) and characteristic mucosal changes in the mouse ileum and cecum", JNCI: Journal of the National Cancer Institute. 87(24), pp. 1876-1883.
6. Saif Muhammad Wasif, Katirtzoglou Nikos A and Syrigos Kostas N (2008), "Capecitabine: an overview of the side effects and their management", Anti-cancer drugs. 19(5), pp. 447-464.
7. Sakai Hiroyasu and et al (2013), "5-Fluorouracil induces diarrhea with changes in the expression of inflammatory cytokines and aquaporins in mouse intestines", PloS one. 8(1), pp. e54788.
8. Wang Yuwei, Meng Long and Liu Xiao (2024), "Capecitabine-associated gastrointestinal ulceration, haemorrhage, and obstruction: a pharmacovigilance analysis based on the FAERS", Frontiers in Pharmacology. 15, pp. 1412938.