NGHIÊN CỨU XÁC ĐỊNH NGƯỠNG CẮT TỐI ƯU CỦA CHỈ SỐ BẠCH CẦU TRUNG TÍNH/LYMPHO (NLR) VÀ TIỂU CẦU/LYMPHO (PLR) TRONG CHẨN ĐOÁN UNG THƯ DẠ DÀY

Abstract

Objective: Gastric cancer (GC) is a common malignancy with high incidence and mortality rates, showing an increasing global trend. Therefore, the development of minimally or non-invasive screening and diagnostic biomarkers for GC is essential. This study aims to determine the optimal cut-off values of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for GC screening and diagnosis. Methods: The study analysed data from 77 GC patients and 90 healthy individuals to establish optimal cut-off values and diagnostic significance for NLR and PLR. Results: The optimal cut-off values for NLR and PLR were determined to be 2.25 and 147.6, respectively, with the highest Youden index values of 0.57 and 0.59. Based on these cut-off values, over 70% of GC patients exhibited increased NLR/PLR, while only about 15% of healthy individuals showed elevated levels. NLR and PLR demonstrated their ability to distinguish GC with respective accuracies of 79.04% and 79.64%. Conclusion: The optimal cut-off values for GC screening and diagnosis are 2.25 for NLR and 147.6 for PLR. These indexes demonstrates strong potential as reliable biomarkers for clinical applications.