SO SÁNH KẾT QUẢ ĐIỀU TRỊ VIÊM ÂM ĐẠO DO NẤM TRÊN THAI PHỤ BẰNG PHÁC ĐỒ CLOTRIMAZOLE 100MG VÀ CLOTRIMAZOLE 500MG: NGHIÊN CỨU CAN THIỆP CÓ ĐỐI CHỨNG

Abstract

Background: A single-dose vaginal tablet regimen of Clotrimazole 500mg has been shown to improve patient compliance and effectively treat fungal vaginitis. However, few studies have directly compared its efficacy with the Clotrimazole 100mg regimen. Objective: To compare the treatment outcomes of fungal vaginitis using Clotrimazole 500mg and 100mg regimens. Materials and methods: A controlled interventional study was conducted on 44 gravid woman diagnosed with fungal vaginitis at Binh Duong Provincial General Hospital. Patients were divided into two groups: Clotrimazole 500mg (n=25) and Clotrimazole 100mg (n=19). Results: The mean age of the patients was 28.6 ± 7.6 years, with 75.0% having at least one child and 72.7% regularly sun-drying their underwear. Among them, 25% had a history of fungal vaginitis, 13.6% had used antibiotics, 11.4% had diabetes, 11.4% practiced vaginal douching, and 11.4% wore tight clothing. There were no statistically significant differences between the two groups regarding these characteristics (p>0.05). At the two-week follow-up, the proportion of patients with negative wet mount microscopy was higher in the Clotrimazole 500mg group than in the 100mg group (88.0% vs. 26.3%, p<0.001). The cure rate after two weeks was also higher in the Clotrimazole 500mg group compared to the 100mg group (88.0% vs. 26.3%, p<0.001). Conclusion: The Clotrimazole 500mg regimen demonstrated superior efficacy in treating fungal vaginitis compared to the Clotrimazole 100mg regimen.