KHẢO SÁT THỰC TRẠNG SỬ DỤNG THUỐC TRONG ĐIỀU TRỊ NHIỄM NẤM XÂM LẤN TẠI BỆNH VIỆN ĐA KHOA THỐNG NHẤT - ĐỒNG NAI NĂM 2024

Abstract

Background: Invasive fungal infections (IFIs) are common infections with high morbidity and mortality rates. Appropriate drug utilization is crucial for optimizing treatment and reducing post-treatment complications; therefore, surveying on the current status of drug use in the treatment of IFIs is necessary. Objective: To survey the current status of drug utilization in the treatment of IFIs at Thong Nhat General Hospital - Dong Nai in 2024. Methods: A cross-sectional descriptive study was conducted based on retrospective data from the medical records of patients with IFIs at Thong Nhat General Hospital - Dong Nai from January 2024 to December 2024. Results: The survey results from 137 patients with invasive fungal infections (IFI) treated at Thong Nhat General Hospital – Dong Nai in 2024 showed that the study sample had a mean age of 61,07 ± 16,43 years, a male-to-female ratio of 1,2:1, and that 84,67% had a risk factor of broad-spectrum antibiotic use, while 57,66% had hypertension as a comorbidity. The analysis of the medication use status for IFI across 155 treatment episodes revealed that the fluconazole monotherapy regimen was the most frequently used (94,19%), with other regimens ranging from 0,5% to 1,29%; 64,95% of medications were domestically sourced. The evaluation of prescribing indicators across 155 treatment episodes involving 20.376 drug prescriptions showed that the average prescription contained 18,68 ± 9,29 drugs; 94,84% of prescriptions included antibiotics; 98,71% included injectable drugs; 29,68% included vitamins; 95,11% of prescribed drugs were generic, 50,3% were administered orally, and 75,57% were domestically sourced. Conclusions: Fluconazole monotherapy was found to be a prevalent treatment regimen for IFIs and prescribing indicators were recorded to be consistent with the real-world clinical practice of the disease.