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Date Published: 18/07/2025
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DOI: https://doi.org/10.51298/vmj.v552i1.14833
Issue
Vol. 552 No. 1 (2025)
Section
Các bài báo
How to Cite
Man Thị Thu, H., & Nguyễn Thế, C. (2025). INITIAL ASSESSMENT OF PRE - TRANSPLANT DESENSITIZATION WITH PLASMA EXCHANGE AT VIETDUC UNIVERSITY HOSPITAL. Vietnam Medical Journal, 552(1). https://doi.org/10.51298/vmj.v552i1.14833

INITIAL ASSESSMENT OF PRE - TRANSPLANT DESENSITIZATION WITH PLASMA EXCHANGE AT VIETDUC UNIVERSITY HOSPITAL

Hương Man Thị Thu, Cường Nguyễn Thế

Main Article Content

Abstract

Background: Kidney transplantation is the optimal treatment for patients with end-stage renal disease. However, due to the limited availability of donor kidneys, the transplant waiting list continues to grow. The presence of donor-specific anti-HLA antibodies (DSAs) remains a significant immunological barrier, increasing the risk of antibody-mediated rejection. Various desensitization strategies, particularly plasma exchange (PEX), have been employed to eliminate DSAs and expand transplant opportunities. Materials and methods: A retrospective descriptive study was conducted on 09 kidney transplant recipients from living donors with pre-existing DSAs, who underwent pre-transplant desensitization using PEX at Viet Duc University Hospital between January 2017 and October 2023. Results: All patients successfully underwent kidney transplantation after PEX-based desensitization. Postoperative renal function improved significantly. No cases of acute rejection or delayed graft function were recorded. After a mean follow-up duration of 25.67 months, all patients remained alive with stable graft function. Conclusion: Pre-transplant desensitization using plasma exchange is a safe and effective strategy, enabling successful kidney transplantation in sensitized patients with DSAs. Further studies are warranted to optimize desensitization protocols and reduce treatment costs.

Article Details

Keywords

kidney transplant, desensitization, DSAs, plasma exchange

References

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