TÌNH TRẠNG GIẢM TIỂU CẦU VÀ MỘT SỐ CHỈ SỐ LIÊN QUAN TIỂU CẦU TRÊN NGƯỜI BỆNH NHIỄM KHUẨN HUYẾT

Abstract

Objective: To describe platelet (PLT) characteristics, related indices (MPV, MPV/PLT, NPR, PLR), and their correlation with biomarkers (CRP, lactate, Procalcitonin) in sepsis patients. Methods: A retrospective, descriptive study on 192 sepsis patients at Military Hospital 103 (1/2024-12/2024). Results: Mean age 65.86 ± 18.03, male 56.8%. Mortality/ discharge request rate 23.4% (45/192). Mean PLT 189.53 ± 117.14 G/l; MPV 9.44 ± 1.50 fL; NPR 0.105 ± 0.143; PLR 308.97 ± 230.74. The mortality/ discharge request group had higher MPV, NPR, PLR than survivors (p < 0.05). MPV correlated positively with CRP (r = 0.38, p < 0.01), lactate (r = 0.35, p < 0.01), PCT (r = 0.34, p < 0.01); MPV/PLT with lactate (r = 0.31, p < 0.01), PCT (r = 0.31, p < 0.01); PLT negatively with CRP (r = -0.15, p < 0.05), lactate (r = -0.29, p < 0.01), PCT (r = -0.30, p < 0.01). Conclusion: Thrombocytopenia is a common condition in sepsis. Platelet-related indices MPV, NPR, and PLR are potential markers for assessing severity and predicting mortality risk in sepsis.