ĐẶC ĐIỂM VÀ YẾU TỐ NGUY CƠ THỞ MÁY Ở TRẺ SỐC SỐT XUẤT HUYẾT DENGUE TẠI BỆNH VIỆN NHI ĐỒNG 1

Abstract

Objective: To describe the clinical characteristics, treatment, and risk factors associated with mechanical ventilation in pediatric patients with dengue shock syndrome (DSS) at Children’s Hospital 1. Subjects and Methods: A longitudinal observational study was conducted from January 2021 to December 2023, involving 113 children diagnosed with DSS. Patients were divided into two groups: those requiring mechanical ventilation (n=31) and those not requiring ventilation (n=82). Clinical, laboratory, and therapeutic parameters were analyzed and compared between the two groups. Results: The mechanically ventilated group had significantly higher rates of severe DSS (64.5% vs. 26.8%) and prolonged shock (32.3% vs. 1.2%, p<0.001). This group also showed markedly elevated levels of lactate, AST, ALT, troponin I, and NT-proBNP, as well as more severe metabolic acidosis. Total fluid volume and duration of fluid resuscitation were significantly greater. Identified risk factors for mechanical ventilation included severe DSS, elevated SIPA scores, increased NT-proBNP, and AST > 1000 IU/L. Conclusion: Children with DSS requiring mechanical ventilation presented with more severe clinical and biochemical disturbances, necessitating more intensive treatment. Early identification of risk factors may improve prognosis in this high-risk population.