ĐÁNH GIÁ HIỆU QUẢ VÀ TÍNH AN TOÀN PHÁC ĐỒ HÓA CHẤT BỔ TRỢ TRƯỚC TRÊN BỆNH NHÂN UNG THƯ BIỂU MÔ VẢY HẠ HỌNG THANH QUẢN GIAI ĐOẠN III-IV

Abstract

Objective: Evaluate the treatment effectiveness and describe side effects of pre-adjuvant chemotherapy regimens in stages III-IV laryngeal and hypopharyngeal squamous carcinoma. Methods: Including 30 patients diagnosed with stages III and IV laryngeal and hypopharyngeal squamous carcinoma. Self-controlled clinical intervention study. Results: All patients were men, average age 55.9±6 years old, mainly presented due to painful and difficult swallow. 24/30 patients (80%) had hypopharyngeal cancer. After 3 cycles of neoadjuvant chemotherapy, 2/30 patients (7%) had a complete response, 27/30 patients (90%) had a partial or stable response, and only 1/30 (3%) patient were badly progressed. The main side effects were nausea in 25/30 patients (83.3%), fatigue in 25/30 patients (83.3%), and hair loss in 30/30 patients (100%). There were 10/30 patients (33.3%) with grade III and IV neutropenia and 4/30 patients (13.3%) with renal dysfunction below 60ml/min/1.73m² of skin. Conclusions: The research shows that after 3 cycles of neoadjuvant chemotherapy, the majority of patients responded partially or were stable, with less symptoms and improved quality of life. Side effects of chemical drugs are safe and acceptable during treatment.