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LYOPHILIZATION TECHNIQUE – EVALUATION OF PLASMA SAMPLES IN EXTERNAL QUALITY ASSESSMENT OF LABORATORY TESTING
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Abstract
Objective: The application of lyophilization techniques has gained increasing attention in the production and preservation of plasma samples for external quality assessment (EQA) in laboratory testing. This study aims to synthesize the results of randomized controlled trials evaluating the effectiveness of using freezing and lyophilization techniques in the production and preservation of plasma samples for EQA programs. Methods: A review was conducted based on nearly 70 selected articles from major electronic databases including PubMed, ScienceDirect, ProQuest, Eli Lilly and Co, and Med Lab Sci, covering the period from 1995 to 2021, following the PRISMA 2020 guidelines. Results: The findings indicate that the application of freezing and lyophilization techniques has yielded highly effective outcomes in EQA programs. Plasma samples preserved using these techniques have demonstrated longer storage durations while maintaining the minimum required levels of essential components
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Keywords
Lyophilization technique, plasma production, external quality assessment, sample preservation and storage.
References
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