ĐÁNH GIÁ TÁC DỤNG KHÁNG KHUẨN CỦA PEPTIDE TỔNG HỢP TRÊN MỘT SỐ CHỦNG VI KHUẨN GÂY VIÊM PHỔI MẮC PHẢI TẠI CỘNG ĐỒNG

Abstract

Objective: To evaluate the antibacterial effects of the synthetic peptide IND-4,11K on several bacterial strains causing community-acquired pneumonia (CAP). Subjects and Methods: This is a prospective, cross-sectional descriptive study assessing the antibacterial activity of the synthetic peptide IND-4,11K on 35 bacterial strains isolated from respiratory specimens of patients with community-acquired pneumonia hospitalized at the Military Hospital 103 from December 2022 to December 2024. Results: Among the isolates, 10/12 Escherichia coli strains were multidrug-resistant (83.3%), 50% of the S. aureus strains were MRSA, 50% of the S. aureus strains were MSSA. The MIC (Minimum Inhibitory Concentration) values of the synthetic peptide IND-4,11K against E. coli and S. aureus strains ranged from 16 µmol/L to 128 µmol/L, while most Pseudomonas aeruginosa strains had MIC values ≥128 µmol/L.Conclusion: The synthetic peptide IND-4,11K demonstrated activity against all S. aureus and E. coli strains with MIC values ranging from 16 µmol/L to 128 µmol/L. Most P. aeruginosa strains had MIC values ≥128 µmol/L.