NGHIÊN CỨU THỜI GIAN KÍCH HOẠT TÂM NHĨ TOÀN BỘ Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÝP 2 BẰNG SIÊU ÂM TIM

Abstract

Introduction: Atrial fibrillation is a common cardiac arrhythmia that can cause stroke and heart failure. The total atrial activation time (TDI) is determined by myocardial tissue Doppler echocardiography (MRI), which is the time from the base of the P wave of the electrocardiogram to the bottom of the A’ wave of the tissue Doppler spectrum at the left atrial wall, just above the mitral valve annulus (PA-TDI (ms)). This parameter reflects the electrical and structural changes of the atria, and has the ability to predict new atrial fibrillation, especially in patients with high cardiovascular risk such as type 2 diabetes mellitus (T2DM). Objective: To evaluate the impact of T2DM on the total atrial activation time compared with normal subjects without clinical cardiovascular disease and without T2DM. Subjects and methods: 49 T2DM patients with an average age of 58.5 ± 11.3 years and 49 normal subjects, of the same age and gender, underwent routine echocardiography and myocardial tissue Doppler ultrasound to determine the PA-TDI interval. Results: PA-TDI in diabetic patients was significantly longer than in normal patients (117.3 ± 15.0 ms vs. 89.9 ± 17.2 ms; p=0.00). In addition, the E/E' ratio was higher, the left atrial volume index was larger in T2DM patients compared to normal subjects, but the difference was not statistically significant (p>0.05). Conclusions: The total atrial activation time in T2DM patients is significantly longer than in normal subjects. Measurement of PA-TDI by transthoracic echocardiography may become a simple, non-invasive method to support early detection of left atrial electrical abnormalities in patients with T2DM in clinical practice.