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DETERMINING ABILITY OF ACELLULAR BOVINE BONE TO SUPPORT VERTICAL BONE AUGMENTATIION ON RABBIT MODEL
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Abstract
Background: Decellularized bovine bone is a valuable material for bone grafting in dentistry; however, no domestically produced commercial product is currently available. Objective: This study aimed to evaluate the bone regeneration potential of decellularized bovine bone particles made in Vietnam by using a rabbit model. Material and methods: Each rabbit was implanted with four titanium cylinders on the calvarial bone. Then, one hole was drilled on the bone’s surface covered by the cylinder. The experimental groups included: no graft (DC), autologous bone graft (TT), commercial bovine bone substitute Bio-Oss® (TM), and decellularized bovine cancellous bone (ThN). After one month, newly formed bone was assessed using CT scans and hematoxylin and eosin (HE) staining. Results: The results showed that bone regeneration occurred in all experimental groups. The hard bone tissue was observed within the tube lumen, with no signs of inflammation. Infiltration of bone marrow cells and formation of new bone trabeculae were evident. Notably, the ThN group exhibited bone regeneration comparable to the commercial TM group, TT group and superior to the DC group. Conclusion: decellularized bovine bone effectively supported new bone formation in the rabbits, indicating its potential as a bone substitute for dental applications.
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Keywords
Ghép xương, xương xốp bò, mô hình thỏ, tái tạo xương, khử tế bào
References
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