Article Sidebar
Views pdf: 25
ASSOCIATION BETWEEN SINGLE NUCLEOTIDE POLYMORPHISMS OF TNF ALPHA GENE AND HEMOLOGICAL INFLAMMATORY INDICATORS IN PSORIASIS VULGARIS
Main Article Content
Abstract
Objective: To investigate the association between single nucleotide polymorphisms of the TNF alpha gene and hematological inflammatory indices in patients with psoriasis vulgaris. Subjects and methods: A cross-sectional study was conducted on 135 Vietnamese patients of Kinh ethnicity at Hospital of Dermato-Vereneology of Ho Chi Minh City from January 2023 to June 2023. Results: The TT genotype frequency of SNP rs1799964 was 60.7%, more than double that of the TC genotype at 31.1% while the CC genotype had the lowest rate of 8.2%. The SII index had a median value of 583.07 K/µl with an interquartile range of 325.84 K/µl. The median values of NLR, MLR and ELR were 1.99, 0.28, 0.07 and the interquartile ranges were 1.16, 0.14 and 0.11, respectively. The mean value of PLR was 119.66 ± 41.78. The CT genotype of SNP rs1799724 accounted for only 10.4% and no TT genotype was detected. There was a statistically significant association between SNP rs1799964 and SII (P = 0.013), NLR (P = 0.012) as well as between SNP rs1799724 and ELR (P = 0.049). Conclusion: There is an association between SNP rs1799964 and SII, NLR as well as between SNP rs1799724 and ELR. This suggests that the SNP may be associated with changes in systemic inflammation in psoriasis patients.
Article Details
Keywords
SNP, hemological inflammatory index
References
2. Sadafi S, Ebrahimi A, Sadeghi M, Emami Aleagha O. Association between tumor necrosis factor-alpha polymorphisms (rs361525, rs1800629, rs1799724, 1800630, and rs1799964) and risk of psoriasis in studies following Hardy-Weinberg equilibrium: A systematic review and meta-analysis. Heliyon. 2023 Jul;9(7):e17552.
3. Albayrak H. Neutrophil-to-Lymphocyte Ratio, Neutrophil-to-Monocyte Ratio, Platelet-to-Lymphocyte Ratio, and Systemic Immune-Inflammation Index in Psoriasis Patients: Response to Treatment with Biological Drugs. J Clin Med. 2023 Aug 22;12(17):5452.
4. Cabaleiro T, Román M, Gallo E, Ochoa D, Tudelilla F, Talegón M, et al. Association between psoriasis and polymorphisms in the TNF, IL12B, and IL23R genes in Spanish patients. Eur J Dermatol EJD. 2013;23(5):640–5.
5. Gallo E, Cabaleiro T, Román M, Abad-Santos F, Daudén E. [Study of genetic polymorphisms in the tumor necrosis factor α promoter region in Spanish patients with psoriasis]. Actas Dermosifiliogr. 2012 May;103(4):301–7.
6. Reich K, Hüffmeier U, König IR, Lascorz J, Lohmann J, Wendler J, et al. TNF polymorphisms in psoriasis: association of psoriatic arthritis with the promoter polymorphism TNF*-857 independent of the PSORS1 risk allele. Arthritis Rheum. 2007 Jun;56(6):2056–64.
7. Daprà V, Ponti R, Lo Curcio G, Archetti M, Dini M, Gavatorta M, et al. Functional study of TNF-α as a promoter of polymorphisms in psoriasis. Ital J Dermatol Venereol. 2022 Apr;157(2):146–53.
8. Gulel A, Inaloz HS, Nursal AF, Sever T, Pehlivan S. Association of the TNF-α, IL-2, and IL-2RB gene variants with susceptibility to psoriasis in a Turkish cohort. Cent-Eur J Immunol. 2018;43(1):50–7.
9. Yorulmaz A, Hayran Y, Akpinar U, Yalcin B. Systemic Immune-Inflammation Index (SII) Predicts Increased Severity in Psoriasis and Psoriatic Arthritis. Curr Health Sci J. 2020;46(4):352–7.
10. Wang Z, Kong L, Zhang H, Sun F, Guo Z, Zhang R, et al. Tumor Necrosis Factor Alpha -308G/A Gene Polymorphisms Combined with Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio Predicts the Efficacy and Safety of Anti-TNF-α Therapy in Patients with Ankylosing Spondylitis, Rheumatoid Arthritis, and Psoriasis Arthritis. Front Pharmacol. 2021;12:811719.