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CHANGES IN PLASMA CONCENTRATIONS OF MATRIX METALLOPROTEINASES IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS DURING AN ACUTE EXACERBATION
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Abstract
Objectives: To describe plasma concentrations of Matrix Metalloproteinase 1, 2, 9, 12 in chronic obstructive pulmonary disease (COPD) patients during an acute exacerbation. Subjects and methods: A Cross-sectional study on 65 COPD patients with acute exacerbation, treated at the Respiratory Medicine Center - Military Hospital 103 and 33 normal people. Quantification of MMP-1, 2, 9, 12 concentration in plasma by ELISA technique. Results: Plasma MMP-9 concentration in COPD patients during acute exacerbation are higher than in normal people (p < 0.05). Plasma MMP-12 levels were higher in patients with non-infectious acute exacerbations, with normal white blood cell counts and CRP. Patients with acute excacerbation who used corticosteroids before admission had lower plasma MMP-1 and MMP-9 concentrations (p < 0.05). Conclusions: In COPD patients with acute exacerbation, plasma MMP-9 concentrations were higher than in normal subjects. Plasma MMP-1 and MMP-9 concentrations were related to previous corticosteroid use.
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Keywords
Chronic obstructive pulmonary disease; Actue exacerbation; Plasma MMPs concentrations
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