LIÊN QUAN GIỮA KIỂU GEN THALASSEMIA VỚI CHỈ SỐ HỒNG CẦU Ở PHỤ NỮ MANG THAI NGƯỜI DÂN TỘC THIỂU SỐ TẠI HUYỆN PHÚ BÌNH, TỈNH THÁI NGUYÊN

Abstract

Objective: to analyse the association between thalassemia genotype and red blood cell index in pregnant ethnic minority women at Phu Binh district, Thai Nguyen province. Methods: A cross-sectional descritive study was conducted on 303 minority ethnic pregnant women at Phu Binh district. Results: The proportion of Tay pregnant women ethnic group was 41.9%, Nung 33.3%; San Diu 12.9% and Dao 6.9%. The proportion of thalassemia gene mutation was 25.1%, including 17.5% α thalassemia, 5.6% β thalassemia, 1.3% HbE and 0.7% combining both α-β thalassemia mutations. There were associations between the gene carrier status and thalassemia type with anemia (p<0.05). There were associations between the gene mutation type and HGB, MCV and MCH indexes (p<0.05). Conclusion: There are associations between the thalassemia gene mutation and genotype with some red blood cell indexes in pregnant ethnic minority women.