THE USE OF AUTOLOGOUS PLATELET-RICH PLASMA IN WOMEN UNDERGOING IN VITRO FERTILIZATION WITH A THIN ENDOMETRIUM

Phương Anh Trần, Phúc Hoàn Nguyễn, Thị Ngọc Yến Trịnh , Thùy Hương Đỗ, Thị Minh Khai Nguyễn, Ngọc Dung Lê, Thị Hạnh Nguyễn, Khang Sơn Nguyễn

Main Article Content

Abstract

Objective: To evaluate the outcomes of frozen embryo transfer in patients with thin endometrium treated with autologous platelet-rich plasma (PRP) infusion in IVF. Subjects and Methods: A retrospective descriptive study including 47 patients with a history of at least 01 embryo transfer cycle cancellation due to thin endometrium at the IVF Center and Tissue Engineering, Hanoi Medical University Hospital, who were treated with PRP infusion and transferred frozen embryos from January 2020 to December 2024. Comparison of endometrial thickness before and after infusion, β-hCG test and evaluation of pregnancy rate (PR), clinical pregnancy rate (CPR) and biochemical pregnancy rate (BPR) after frozen embryo transfer. Results: The thickness of the endometrium after PRP infusion increased significantly compared to before (7.86 ± 0.91 mm vs 6.79 ± 0.80 mm, p<0.001). The pregnancy rate (PR), clinical pregnancy rate (CPR) and biochemical pregnancy rate (BPR) were 53.19%, 40.4% and 6.38% respectively. Conclusions: Intrauterine autologous PRP infusion improved significantly the endometrial thickness and successful rate in IVF in some patients with thin endometrium

Article Details

References

Al-Ghamdi A, Coskun S, Al-Hassan S, Al-Rejjal R, Awartani K. The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome. Reprod Biol Endocrinol RBE. 2008;6:37. doi:10.1186/1477-7827-6-37
2. El-Toukhy T, Coomarasamy A, Khairy M, et al. The relationship between endometrial thickness and outcome of medicated frozen embryo replacement cycles. Fertil Steril. 2008; 89(4): 832-839. doi:10.1016/j.fertnstert. 2007.04.031
3. Amui J, Check JH, Cohen R. Successful twin pregnancy in a donor oocyte recipient despite a maximum endometrial thickness in the late proliferative phase of 4 mm. Clin Exp Obstet Gynecol. 2011;38(4):328-329.
4. Shimizu T, Jiang JY, Sasada H, Sato E. Changes of messenger RNA expression of angiogenic factors and related receptors during follicular development in gilts. Biol Reprod. 2002; 67(6): 1846-1852. doi:10.1095/biolreprod. 102.006734
5. Sugino N, Suzuki T, Sakata A, et al. Angiogenesis in the human corpus luteum: changes in expression of angiopoietins in the corpus luteum throughout the menstrual cycle and in early pregnancy. J Clin Endocrinol Metab. 2005; 90(11): 6141-6148. doi:10.1210/jc.2005-0643
6. Eftekhar M, Neghab N, Naghshineh E, Khani P. Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial. Taiwan J Obstet Gynecol. 2018;57(6): 810-813. doi:10.1016/j.tjog. 2018.10.007
7. Kim H, Shin JE, Koo HS, Kwon H, Choi DH, Kim JH. Effect of Autologous Platelet-Rich Plasma Treatment on Refractory Thin Endometrium During the Frozen Embryo Transfer Cycle: A Pilot Study. Front Endocrinol. 2019; 10:61. doi:10. 3389/fendo.2019.00061
8. Chang Y, Li J, Wei LN, Pang J, Chen J, Liang X. Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium. Medicine (Baltimore). 2019;98(3):e14062. doi:10. 1097/MD.0000000000014062