MỐI LIÊN QUAN GIỮA BIỂU HIỆN GEN NF-ΚB P65, NF-ΚB P50 TRONG MÔ U GAN VỚI MỘT SỐ ĐẶC ĐIỂM KHỐI U Ở BỆNH NHÂN UNG THƯ BIỂU MÔ TẾ BÀO GAN CÓ HBSAG (+)

Abstract

Objective: To investigate the expression levels of NF-κB p50 and NF-κB p65 genes in tumor tissues and their association with clinicopathological characteristics in HBsAg-positive Hepatocellular carcinoma (HCC) patients. Subjects and methods: A cross-sectional descriptive study was conducted on 69 patients who underwent hepatectomy for HCC from July 2022 to July 2024. The expression of NF-κB p50 and NF-κB p65 in paired tumor and adjacent non-tumorous tissues was quantified by RT-qPCR. Results: The expression of NF-κB p65, p50 genes had no statistically significant difference in cancer tissue samples compared to adjacent tumor tissue samples (Median (quartiles) were: 1,43 ((-5,18) – 4,73) compared (-0,08) ((-4,38) – 4,02); p = 0,85); and (-4,87) ((-9,41) – (-0,93)) compared (-2,38) ((-8,17) – 4,11); p = 0,07, respectively; p < 0,0001). There was no correlation between the relative expression levels of NF- κB p65, NF- κB p50 genes in cancer tissue and some characteristics of the tumor (size, number, portal vein thrombosis) and pathology (structure, vascular invasion in the tumor, cirrhosis). Conclusion: NF-κB p50, NF-κB p65 genes weren’t increased in tumor tissue compared to adjacent tumor tissue. There was no correlation between the relative expression levels of NF-κB p50 and NF-κB p65 genes in cancer tissue and some features of the tumor and pathology.