KHẢO SÁT SỰ LIÊN QUAN CỦA TÌNH TRẠNG LO ÂU CĂNG THẲNG VỚI MỨC ĐỘ ĐÁP ỨNG VIÊM VÀ ĐỘNG MẠCH VÀNH THỦ PHẠM Ở BỆNH NHÂN NHỒI MÁU CƠ TIM CẤP

Abstract

Objective: To investigate the association between psychological stress and anxiety with inflammatory response and culprit coronary artery in patients with acute myocardial infarction (AMI). Methods: A cross-sectional study was conducted on 98 AMI patients undergoing percutaneous coronary intervention at Military Hospital 175 (June 2024–May 2025). Psychological stress and depression were assessed using the Perceived Stress Scale-10 (PSS-10) and Patient Health Questionnaire-9 (PHQ-9). Inflammatory markers included neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). The culprit artery (LAD, RCA, LCx) was identified by coronary angiography. Statistical analysis was performed using Spearman correlation, ANOVA, and Kruskal–Wallis test. Results: The mean age was 63,3 ± 10,3 years; 59,2% were male. Hypertension was present in 78,6%, diabetes in 44,9%, and dyslipidemia in 63,3%. The mean PSS-10 score was 18,1 ± 2,0 (moderate stress level); 14,3% had mild depression by PHQ-9. The mean NLR was 2,97 ± 2,20 and PLR was 134,5 ± 57,6. The culprit artery distribution was LAD 45,9%, RCA 35,7%, LCx 17,3%, and LM-LAD 1,0%. Spearman correlation showed no significant association between PSS-10/PHQ-9 scores and NLR or PLR (p > 0,05). No significant differences in PSS-10 and PHQ-9 scores were observed among LAD, RCA, and LCx groups (p > 0,05). Conclusions: Psychological stress and mild depressive symptoms are common in AMI patients. However, no significant association was found between stress/depression scores and inflammatory markers (NLR, PLR) or culprit artery location. Early psychological screening and intervention remain necessary to improve quality of life and treatment adherence.