ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG NGỘ ĐỘC CẤP METHANOL

Abstract

Objective: to assess clinical characteristics and laboratory abnormalities of patients with acute methanol poisoning. Subjects and Methods: A observational study included 107 methanol poisoned patients treated at Poison Control Center of Bach Mai Hospital from January 2016 to July 2019. Results: The study patients were mainly male (97.2%), the mean age were 47.6 ± 12.6 years old. The mortality was high (41.1%). Clinical features: headache and blurred vision most frequently encountered (94.4%), the were deep comma (63.6%), dilated pupils (61.7%), loss of light reflection (45.8%), respiratory failure (79.4%), acute renal failure (54.2%), hypotension (31.8%). Seizures were not common (6.5%). The rates of severe symtomps was higher in the fatal group. Laboratory features: severe metabolic acidosis, OG, AG, CK, lactate, blood glucose were all high, and the indicators of the mortality group were much higher. Methanol concentration was high (157.1 ± 90.06 mg/Dl). Neurological damages on CT/MRI were 63.4%. Eye damage 62.9% (vision damage 37.1%; papillary edema 21.4%; retinal hemorrhage 4.3%). Conlusion: Methanol poisoning had the characteristics and signs of severe multiple organs failures, high mortality.