Article Sidebar

PDF
Date Published: 08/06/2021
Abstract Views: 156
Views PDF: 156
DOI: https://doi.org/10.51298/vmj.v500i1.302
Issue
Vol. 500 No. 1 (2021)
Section
Các bài báo
How to Cite
Thị Xuân, Đặng . (2021). EFFECTIVENESS OF ORAL ETHANOL THERAPY PROTOCOL IN THE TREATMENT OF ACUTE METHANOL POISONINGS. Vietnam Medical Journal, 500(1). https://doi.org/10.51298/vmj.v500i1.302

EFFECTIVENESS OF ORAL ETHANOL THERAPY PROTOCOL IN THE TREATMENT OF ACUTE METHANOL POISONINGS

Đặng Thị Xuân

Main Article Content

Abstract

Objective: To evaluate the effectiveness of oral ethanol regimen in the treatment of the patients with acute methanol poisoning. Subjects and methods: The study included 61 patients with acute methanol intoxication treated at Poison Control Center (PCC) of Bach Mai Hospital from October 2016 to July 2018 who were indicated ethanol 20% orally according to the protocol. Results: Average age was 46.7 ± 15 (16-71) years old, male accounted for 93.4%. Blood methanol concentration was very high, median is 126 (20 - 569.7) mg/dL. Applying the regimen, the blood ethanol concentration gradually increased, the majority (37/61 patients) achieved the target after 3.4 ± 2.36 hours (60.7%), there were 16/61 patients who did not reach the target ethanol concentration (26.2%), with 8 out of 61 patients developed ethanol overdose (13.1%). Median duration of the treatment was 4 (1-12) days. 28 patients survival (45.9%), 13 patients with sequelae (21.3%) and 20 patients died, accounting for 32.8%. Conclusions: The study showed that the use of an oral ethanol protocol was effective in the treatment of acute methanol poisoning

Article Details

Keywords

acute methanol poisoning, oral ethanol

References

1. Zakhazov S, et al. (2015). Fluctuations in serum ethanol concentration in the treatment of acute methanol poisoning: a prospective study of 21 patients. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 159
2. Phạm Như Quỳnh, Lê Đình Tùng, Hà Trần Hưng (2017). Hiệu quả của thẩm tách máu kéo dài trong điều trị bệnh nhân ngộ độc cấp methanol. Tạp chí Sinh lý học Việt Nam, 21(3), 13-20.
3. Nguyễn Đàm Chính, Hà Trần Hưng (2016). Nhận xét kết quả điều trị bệnh nhân ngộ độc cấp methanol tại Trung tâm chống độc bệnh viện Bạch Mai.Tạp chí nghiên cứu y học,440(1),29-33
4. McMartin K, Jacobsen D, Hovda K.E. (2015). Antidotes for poisoning by alcohols that form toxic metabolites, British Journal of Clinical Pharmacology.
5. Girault C, et al, (1999). Fomepizole (4-methylpyrazole) in fatal methanol poisoning with early CT scan cerebral lesions. J Toxicol Clin Toxicol, 37(6), 777-80.
6. Rietjens S.J, D.W. de Lange, and J. Meulenbelt(2014). Ethylene glycol or methanol intoxication: which antidote should be used, fomepizole or ethanol? Neth J Med, 2014. 72(2), 73-9.
7. Barceloux D.G, et al. (2002). American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning. J Toxicol Clin Toxicol, 40(4), 415-46
8. Lee C.Y, et al, (2014). Risk factors for mortality in Asian Taiwanese patients with methanol poisoning. Ther Clin Risk Manag, 10, 61-7.
9. Wedge M.K, et al. (2012). The safety of ethanol infusions for the treatment of methanol or ethylene glycol intoxication: an observational study, Canadian Association of Emergency Physicians CJEM, 14(5), 283-289.