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Date Published: 08/06/2021
Abstract Views: 491
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DOI: https://doi.org/10.51298/vmj.v500i1.325
Issue
Vol. 500 No. 1 (2021)
Section
Các bài báo
How to Cite
Chí Dũng, V. ., & Quang Thanh, T. . (2021). FACTORS ASSOCIATED WITH PRESENCE AND SEVERITY AND OUTCOME OF DIABETIC KETOACIDOSIS IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES. Vietnam Medical Journal, 500(1). https://doi.org/10.51298/vmj.v500i1.325

FACTORS ASSOCIATED WITH PRESENCE AND SEVERITY AND OUTCOME OF DIABETIC KETOACIDOSIS IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES

Vũ Chí Dũng, Trần Quang Thanh

Main Article Content

Abstract

Type 1 diabetes mellitus (T1MD) is one of the most common endocrine diseases
in children. Diabetic ketoacidosis (DKA) is the most serious life-threatening acute complication of T1MD. Younger age, particularly < 2 years, low accessibility to medical care, ethnic minority groups and diagnostic error were identifed as risk factors for DKA at T1DM diagnosis. Determining the risk factors for developing DKA plays an important role in diagnosing, treating and reducing the rate and serevity of the disease. Objective: to describe the risk factors and outcome of DKA in children and adolescents. Subjects: 212 patients with type 1 diabetes at diagnosis at the National Children’s Hospital (NCH) from 6/2015 to 6/2020. Methods: case series study. Results: 212 patients with type 1 diabetes at diagnosis at the NCH from 6/2015 to 6/2020. Sixty patients (28.3%) were diagnosed with DKA; serum C-peptide levels were lower 1,1 ng/ml increased the risks for DKA (OR, 5,13; 95% CI, 1,72 – 15,29), increased the risks for severe DKA (OR, 2,13; 95% CI, 0,20 – 22,21), diagnostic error increased the risks for severe DKA (OR, 6,42; 95% CI, 1,20–34,19). The mean
time for the arterial blood gases to become normal was 22,5 hours. Acute kidney injury developed in 15 patients (30%). There were no deceased patients. Conclusion: The rate of DKA in patients with T1DM for the first time at NCH was high. Serum C-peptide levels were lower 1,1 ng/ml, diagnostic error increased the risks for DKA and severity of DKA. Acute kidney injury is a common complication of DKA.

Article Details

Keywords

Type 1 diabetes, Diabetic ketoacidosis

References

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