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Date Published: 12/06/2021
Abstract Views: 396
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DOI: https://doi.org/10.51298/vmj.v500i2.351
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Vol. 500 No. 2 (2021)
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Các bài báo
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Thị Hồng Thanh, L. ., & Văn Em, Đặng . (2021). EVALUATED THE CONCENTRATION OF CYTOKINES IN SEVERE PSORIASIS VULGARIS WAS TREATED BY CYCLOSPORINE A. Vietnam Medical Journal, 500(2). https://doi.org/10.51298/vmj.v500i2.351

EVALUATED THE CONCENTRATION OF CYTOKINES IN SEVERE PSORIASIS VULGARIS WAS TREATED BY CYCLOSPORINE A

Lê Thị Hồng Thanh, Đặng Văn Em

Main Article Content

Abstract

Objective: To evaluated the concentration of cytokines: IL-2, IL-6, IL-8, IL-10, IL-12, IL-17, INF-, TNF-α in patients with severe psoriasis vulgaris was treated by Cyclosporine A. Subject and method: 35 out-patients with severe psoriasis vulgaris had treated at National Dermatology Hospital from October2016 to October 2019were quantified concentration of cytokines IL-2, IL-6, IL -8, IL-10, IL-12, IL-17, INF-, TNF-α in serum before and after treatment with Cyclosporine A (daily dose 2,5-3mg/kg/day) in 10 weeks. Result: The concentration of cytokines IL-2, IL-6, IL-8, IL-10, IL-12, IL-17, TNF-α before and after treatment was not changed that has statistically significant with p>0.05. However, the concentration of INF-after treatment reduced that significantly, with p<0.05. Conclusion: Patients with severe psoriasis vulgaris were treated by Cyclosporine A (daily dose 2,5-3mg/kg/day) have not changed the concentrations of IL-2, IL-6, IL-8, IL-10, IL-12, IL-17, TNF-α after 10 weeks. However, the concentration of INF-has reduced that statisticallysignificantly.

Article Details

Keywords

Severe psoriaisis vulgaris, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, INF-, TNF-α

References

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