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Date Published: 05/07/2023
Abstract Views: 431
Views PDF: 151
DOI: https://doi.org/10.51298/vmj.v527i2.5908
Issue
Vol. 527 No. 2 (2023)
Section
Các bài báo
How to Cite
Nguyễn, N. N., Mai, H. N. T., & Huỳnh, M. G. (2023). ANTI-SARS-COV-2 ANTIBODY LEVELS AFTER FOURTH DOES OF COVID-19 VACCINE IN PATIENTS WITH END-STAGE RENAL DISEASE. Vietnam Medical Journal, 527(2). https://doi.org/10.51298/vmj.v527i2.5908

ANTI-SARS-COV-2 ANTIBODY LEVELS AFTER FOURTH DOES OF COVID-19 VACCINE IN PATIENTS WITH END-STAGE RENAL DISEASE

Như Nghĩa Nguyễn1,, Huỳnh Ngọc Tân Mai1, Minh Giàu Huỳnh2
1 Can Tho University of Medicine - Pharmacy
2 Giong Rieng District Medical Center

Main Article Content

Abstract

December 2019, seriously affecting the health of everyone, including patients with chronic kidney disease. By 2021, Vietnam has implemented vaccination against Covid-19, and there have been some initial studies evaluating antibody against SARS-CoV-2 virus after vaccination. However, most of the research was conducted on normal people, 1 to 2 doses after vaccination. Objectives: to evaluate levels of antibodies targeting the receptor binding protein (anti-RBD) after 4th dose of Covid-19 vaccine and some related factors in chronic kidney disease patients on hemodialysis at Can Tho General Hospital. Subjects and method: a cross-sectional descriptive study in 52 end-stage renal disease (ESRD) patients on hemodialysis at Can Tho General hospital, at least 4 weeks after 4th dose of Covid-19 vaccine, from July 2022 to January 2023. Results: men were 50%, the mean age was 51,6±12,9, mean time on hemodialysis was 6,77±3,44 years. All patients with ESRD disease had anti-RBD IgG antibodies after receiving 4 doses of Covid-19 vaccine, the average antibodies concentration was 1237.13±6021.96 AU/mL. Patients with multiple comorbidities had lower antibody levels than the group with 1 comorbidity. Anti-RBD IgG antibody concentrations were much lower in the smokers group than in the non-smokers (8182.0±3720.14 AU/mL vs 13505.0±6052.49 AU/mL, p=0.001). There was a moderate inverse correlation between the anti-RBD IgG antibody levels and the age of the patient (r= -0.32, p=0.03). Conclusions: 4 doses of Covid-19 vaccine have high antibody production efficiency in patients with end-stage renal disease.

Article Details

Keywords

: Covid-19, ESRD, vaccine, Can Tho.

References

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