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RELATIONSHIP, CORRELATION BETWEEN PLASMA NT-proBNP CONCENTRATION WITH CARDIAC MORPHOLOGY AND FUNCTION IN HEART FAILURE PATIENTS DUE TO VALVULAR DISEASE
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Abstract
Aim: To determine the relationship and correlation between NT-pro BNP levels with mophology and cardiac function in patients with heart failure due to valvular heart disease. Objects and methods: 82 patients, 36 men, 46 women, mean age 66.04±16.2, were diagnosed with heart failure according to Framingham criteria and identified with true valvular disease (mitral stenosis, mitral regurgitation, aortic stenosis, aortic regurgitation, tricuspid valve disease, pulmonary valve disease) according to echocardiography. All patients were evaluated for cardiac function (EF) and cardiac morphometric indices by Doppler ultrasound and had a quantitative NT-pro BNP test using an immunoassay machine. Result: There is a strong negative correlation between NT-proBNP concentration and ejection fraction (EF) with r=-0.75; p<0.001. There was a positive correlation between NT-proBNP concentration and left ventricular diastolic diameter LVDd with r=0.63; p<0.001. There was a positive correlation between NT-proBNP concentration and left ventricular muscle mass (LVM) with r=0.53; p<0.001. There is a positive correlation between NT-proBNP concentration and left ventricular muscle index (LVMI) with r=0.59; p<0.001. Conclusion: There is a strong negative correlation between NT-proBNP concentration and left ventricular systolic function and there is a positive correlation between NT-proBNP concentration and left ventricular muscle mass, left ventricular mass index and left ventricle diameter
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References
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