ĐÁNH GIÁ KẾT QUẢ BỔ TRỢ TRƯỚC UNG THƯ VÚ BỘ BA ÂM TÍNH GIAI ĐOẠN II-III TẠI BỆNH VIỆN K, GIAI ĐOẠN 2020 – 2022

Abstract

Objectives: To evaluate of response with neoadjuvant chemotherapy triple negative breast cancer and some adverse events the regimen. Patients and method: 24 patients triple negative breast cancer treated with neoadjuvant chemotherapy at K Hospital from October 2020 to October 2022. Results: The median age is 51. The initial stage of tumor is mainly T2, and T3: 50%, 16.7%, respectively. All of  patients with complete clinical respone. 25% complete respone, 75% partial response disease. The histopathological complete response rate (pCR: ypT0/is-ypN0) was 25%. All of patients changed from inoperable to operable. The rate of complete response on histopathology at the tumor is related to the status of axillary lymph nodes after surgery. To the adverse events of neoadjuvant chemotherpy: neutrophils, thrombocytopenia, mainly at grade 1, 2,  9.2% neutropenia patients had grade 3, 4. Hepatotoxicity patients seen 25%, of which 4.1% were at grade 3. Vomiting, peripheral neuropathy mainly grade 1, 2, no cases grade 3, 4.