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Date Published: 05/07/2023
Abstract Views: 670
Views PDF: 245
DOI: https://doi.org/10.51298/vmj.v527i2.5927
Issue
Vol. 527 No. 2 (2023)
Section
Các bài báo
How to Cite
Phạm, H. P., Trần, T. H., Hồ, T. P., Diệp, T. M. T., Võ, D. T., & Trần, V. A. (2023). THE EFFICACY OF BISMUTH-CONTAINING QUADRUPLE VERSUS LEVOFLOXACIN TRIPLE THERAPIES AS RESCUE TREATMENT FOR HELICOBACTER PYLORI ERADICATION. Vietnam Medical Journal, 527(2). https://doi.org/10.51298/vmj.v527i2.5927

THE EFFICACY OF BISMUTH-CONTAINING QUADRUPLE VERSUS LEVOFLOXACIN TRIPLE THERAPIES AS RESCUE TREATMENT FOR HELICOBACTER PYLORI ERADICATION

Hùng Phong Phạm1, Thanh Hưng Trần1, Tấn Phát Hồ1, Thị Mộng Tuyền Diệp1, Duy Thông Võ1,2, Viết An Trần3
1 Cho Ray Hospital
2 University of Medicine and Pharmacy at Ho Chi Minh City
3 Can Tho University of Medicine - Pharmacy

Main Article Content

Abstract

Background: Helicobacter pylori (H.pylori) is a super-mutant bacteria that causes different immune responses in patients. Objectives: To evaluate the efficacy of H.pylori eradication of 4-drug regimens with Bismuth and 3-drug regimens with levofloxacin in patients with peptic ulcer disease who failed H.pylori treatment. Materials and methods: Descriptive study of a series of cases into 2 groups treated with 4-drug regimen containing Bismuth and group treated with 3-drug regimen containing Levofloxacin from June 2017 to August 2018. Patients were randomly selected when visiting on weekdays, at the outpatient department of Gastroenterology, Cho Ray Hospital. Results: 72.5% patients had a history of eradication failure 1 time, the history of using OAC regimen accounts for a higher rate than other regimens (50%.). Image of lesions on endoscopy: gastritis is the most common lesion (before treatment: 69.2% and after treatment 37.5%. The overall treatment response rate of the study was 88.3%. The rate of treatment response in group 3 drugs with Levofloxacin was 85,0%, group 4 drugs with bismuth was 91.7% (p > 0.05). The rate of side effects in the study was 101 cases (84.2%). Adherence to treatment had a statistically significant relationship with the treatment outcome (p < 0.001). Conclusion: Explain and guide the patient how to use the drug, and recommend prioritizing a 4-drug regimen with Bisthmus in patients with prior treatment failure.

Article Details

Keywords

H.pylori eradication regimen, drug resistance, Levofloxacin

References

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