Article Sidebar

pdf
Date Published: 30/08/2023
Abstract Views: 143
Views pdf: 96
DOI: https://doi.org/10.51298/vmj.v529i1B.6332
Issue
Vol. 529 No. 1B (2023)
Section
Các bài báo
How to Cite
Trần, X. Y., Nguyễn, V. B. ., Nguyễn, H. H., Võ , V. X., & Trịnh, L. H. (2023). RESULTS OF CONCURRENT CHEMORADIOTHERAPY BY INTENSITY MODULATED RADIATION THERAPY FOR TREATING UPPER THIRD ESOPHAGEAL CANCER AT NGHE AN ONCOLOGY HOSPITAL. Vietnam Medical Journal, 529(1B). https://doi.org/10.51298/vmj.v529i1B.6332

RESULTS OF CONCURRENT CHEMORADIOTHERAPY BY INTENSITY MODULATED RADIATION THERAPY FOR TREATING UPPER THIRD ESOPHAGEAL CANCER AT NGHE AN ONCOLOGY HOSPITAL

Xuân Yên Trần1, Viết Bình Nguyễn1, Hải Hoàng Nguyễn1, Văn Xuân Võ 2, Lê Huy Trịnh3
1 Nghe An Oncology Hospital
2 K hospital
3 HMU

Main Article Content

Abstract

Objective: To evaluate the outcomes of treatment for upper third esophageal cancer using a combined intensity modulated radiation therapy (IMRT) and CF chemotherapy regimen at Nghe An Oncology Hospital. Subjects and Methods: A descriptive retrospective study was conducted on 40 patients with stage II-IVa upper third esophageal cancer at Nghe An Oncology Hospital from April 2019 to June 2023. Results: The patients in the study had a mean age of 57.98 ± 7.69 years, with 97.5% being male. The percentage of patients in stage II, stage III, and stage IVa of the disease was 15%, 30%, and 55% respectively. The complete response rate after concurrent chemoradiotherapy was 27.5%, and the overall treatment process resulted in a response rate of 40%. There was one patient who experienced liver metastasis. The average overall survival (OS) was 18.81 ± 2.06 months, with a 95% confidence interval ranging from 14.79 months to 22.84 months. The OS was statistically significant in relation to treatment response (p<0.05), but the difference in OS between disease stages was not statistically significant (p>0.05). The toxicity of the treatment regimen was mainly grade 1 and grade 2, and there were no cases of severe toxicity. Conclusion: Treatment of upper third esophageal cancer with IMRT and CF chemotherapy regimen resulted in relatively high treatment efficacy and low toxicity.

Article Details

Keywords

Upper third esophageal cancer, intensity modulated radiation therapy (IMRT), Cis-5FU regimen, concurrent chemoradiotherapy.

References

1. Sung H., Ferlay J., Siegel R.L., et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), (2021), 209–249.
2. Bộ Y tế, Hướng dẫn chẩn đoán và điều trị một số bệnh ung bướu, Nhà xuất bản Y học, (2020), 264-279.
3. Intensity Modulated Radiation Therapy Collaborative Working Group. Intensity-modulated radiotherapy: current status and issues of interest. Int J Radiat Oncol Biol Phys, 51(4), (2001), 880–914.
4. Linh Dương Thùy. Đánh giá kết quả hóa xạ trị điều biến liều bệnh ung thư thực quản 13 trên, Luận văn thạc sĩ y học, Trường Đại học Y Hà Nội, (2018).
5. Tuấn Vũ Minh. Đánh giá kết quả hóa trị đồng thời triệt căn ung thư thực quản giai đoạn II-III Luận văn thạc sĩ y học, Trường Đại học Y Hà Nội, (2020).
6. Roeder F., Nicolay N.H., Nguyen T., et al. Intensity modulated radiotherapy (IMRT) with concurrent chemotherapy as definitive treatment of locally advanced esophageal cancer. Radiation Oncology, 9(1), (2014), 191.
7. Shi A., Liao Z., Allen P.K., et al. Long-term survival and toxicity outcomes of intensity modulated radiation therapy for the treatment of esophageal cancer: A large single-institutional cohort study. Adv Radiat Oncol, 2(3), (2017), 316–324.
8. Wang S.-L., Liao Z., Liu H., et al. Intensity-modulated radiation therapy with concurrent chemotherapy for locally advanced cervical and upper thoracic esophageal cancer. World J Gastroenterol, 12(34), (2006), 5501–5508.