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THE PROBIOTIC EFFECT OF LACTOBACILLUS REUTERI IN SUPPORTING NON-SURGICAL PERIODONTAL TREATMENT
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Abstract
Purpose: The use of adjunctive methods in the treatment of periodontitis is becoming increasingly popular due to their positive effects on the oral microbiota and immune response in periodontal tissues. The objective of this study is to evaluate the efficacy of probiotic supplements containing Lactobacillus reuteri in the non-surgical treatment (NST) of periodontitis. Materials and methods: 26 patients with periodontitis were randomly divided into two groups: test group (NST + probiotic) and control group (NST + placebo). Probiotic tablets or placebos were administered twice daily for 4 weeks following the non-surgical periodontal treatment. Subgingival plaque samples were collected at baseline (T0), 2 weeks (T1), and 4 weeks (T2) after the treatment. The levels of Porphyromonas gingivalis (Pg), Treponema denticola (Td), Tannerella forsythia (Tf), and Fusobacterium nucleatum (Fn) in the plaque were quantified using real-time PCR. Result: At T1 and T2, there was a significant reduction in the levels of pathogenic bacteria compared to baseline in both the intervention and control groups. However, there was no significant difference in the levels of the target bacteria between the two groups at each time point. Conclusion: Within the limitations of the study, the use of probiotic supplementation helped reduce periodontal pathogenic bacteria in patients with periodontitis. However, there was no clear difference in effectiveness compared to the sole non-surgical treatment
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Keywords
periodontitis, probiotics, microbiological effect
References
1. Tekce M, Ince G, Gursoy H, et al. Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1‐year follow‐up study. 2015;42(4):363-372.
2. Teughels W, Durukan A, Ozcelik O, Pauwels M, Quirynen M, Haytac MCJJocp. Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo‐controlled study. 2013;40(11):1025-1035.
3. Laleman I, Pauwels M, Quirynen M, Teughels WJJoCP. A dual‐strain Lactobacilli reuteri probiotic improves the treatment of residual pockets: A randomized controlled clinical trial. 2020;47(1):43-53.
4. Ausenda F, Barbera E, Cotti E, Romeo E, Natto ZS, Valente NAJJDSR. Clinical, microbiological and immunological short, medium and long-term effects of different strains of probiotics as an adjunct to non-surgical periodontal therapy in patients with periodontitis. Systematic review with meta-analysis. 2023; 59:62-103.
5. Nguyen T, Brody H, Radaic A, Kapila YJP. Probiotics for periodontal health—Current molecular findings. 2021;87(1):254-267.
6. Ochôa C, Castro F, Bulhosa JF, Manso C, Fernandes JCH, Fernandes GVOJM. Influence of the Probiotic L. reuteri on Periodontal Clinical Parameters after Nonsurgical Treatment: A Systematic Review. 2023;11(6):1449.
7. Belstrøm D, Grande MA, Sembler‐Møller ML, et al. Influence of periodontal treatment on subgingival and salivary microbiotas. 2018;89(5):531-539.
8. Pelekos G, Acharya A, Eiji N, Hong G, Leung WK, McGrath CJJoCP. Effects of adjunctive probiotic L. reuteri lozenges on S/RSD outcomes at molar sites with deep pockets. 2020;47(9):1098-1107.