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Ngày xuất bản: 02/12/2023
Số lượt xem tóm tắt: 60
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DOI: https://doi.org/10.51298/vmj.v532i2.7392
Số xuất bản
Tập 532 Số 2 (2023): Vietnam Medical Journal
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Hue , V. T., Anh, D. N., Thanh , T. T., & Dinh, T. C. (2023). THE EXPRESSION OF SFRP5 ON ADIPOSE TISSUES AND ITS ASSOCIATION WITH METABOLIC DISORDERS: A SYSTEMATIC REVIEW . Tạp Chí Y học Việt Nam, 532(2). https://doi.org/10.51298/vmj.v532i2.7392

THE EXPRESSION OF SFRP5 ON ADIPOSE TISSUES AND ITS ASSOCIATION WITH METABOLIC DISORDERS: A SYSTEMATIC REVIEW

Hue Vu Thi1,, Anh Dao Ngo2, Thanh Thuy To3, Dinh Toi Chu4,5
1 Center for Biomedicine and Community Health, International School, Vietnam National
2 Faculty of Applied Sciences, International
3 Faculty of Biology, VNU University of Science
4 Center for Biomedicine and Community Health, International School, Vietnam National University
5 Faculty of Applied Sciences, International School, Vietnam National University

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Tóm tắt

Objectives: This study aims to provide a comprehensive overview of the expression of Secreted Frizzled-related Protein 5 (Sfrp5) in adipose tissues and its association with metabolic disorders. Subjects and Methods: A systematic review was conducted. PRISMA guidelines and PICOT standards were used in this study. We searched the data using two search databases (PubMed and ScienceDirect). Results: Based on two databases, we identified 1853 potentially relevant articles. 10 documents that met all selection criteria were selected. Most articles showed that the expression of Sfrp5 increased in adipose tissues of mice fed a high-fat diet (HFD) for 8 weeks (n=1), at 16 weeks of mouse age (n=1), and in obese people (n=1). In addition, Sfrp5 was reported to have the higher expression in the DBA/2J strain (n=1), in the epididymal adipose tissue (n=1), in NASH patients (n=1), and in the presence of PPARγ (n=1). In contrast, some studies have shown that the expression of Sfrp5 has decreased significantly in the adipose tissue when B6 mice when ingested HFD for 12 weeks (n=1), at 16-31 weeks of mouse age (n=1), and in leptin-deficient mice when eating an HFD until 21-day-year old (n=1). However, a study had shown that the expression of Sfrp5 decreased when fat accumulation reached a stable level. This study seems to open up an explanation for the inconsistent evidence. These results have highlighted that Sfrp5 expression strongly correlates with obesity; thus, potential application directions have been shown in treating and preventing obesity (n=4). At the same time, the application potential of sfrp5 in cardiovascular diseases and fatty liver has also been proposed. Conclusion: Sfrp5 is a newly discovered protein in terms of function, so the evidence for Sfrp5 expression on adipose tissue has many gaps to exploit. Further studies, especially nutritional interventions, need to be carried out to elucidate its potential application to metabolic disorders.

Chi tiết bài viết

Từ khóa

Sfrp5; expression; adipocytes; adipose tissues; metabolic disorders.

Tài liệu tham khảo

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