Article Sidebar

PDF
Date Published: 11/12/2023
Abstract Views: 341
Views PDF: 131
DOI: https://doi.org/10.51298/vmj.v532i2.7630
Issue
Vol. 532 No. 2 (2023)
Section
Các bài báo
How to Cite
Lê, H. L., Trần, T. H. Y., Lê, Q. V., Đào, D. Q., Phạm, T. T. Y., Lưu, T. H., Nguyễn, T. T. H., & Nguyễn, Đình Q. (2023). IMMUNOHISTOCHEMIAL EXPRESSION OF P16 AND P53 IN HIGH – GRADE SQUAMOUS INTRAEPITHELIAL LESION. Vietnam Medical Journal, 532(2). https://doi.org/10.51298/vmj.v532i2.7630

IMMUNOHISTOCHEMIAL EXPRESSION OF P16 AND P53 IN HIGH – GRADE SQUAMOUS INTRAEPITHELIAL LESION

Hoàng Linh Lê1, Thị Hải Yến Trần1, Quang Vinh Lê1,, Duy Quân Đào1, Thị Thanh Yên Phạm1, Thị Hồng Lưu1, Thị Thu Hoài Nguyễn1, Đình Quyết Nguyễn1
1 Central maternity hospital

Main Article Content

Abstract

Objectives: Determining immunohistochemical expression of p16 and p53 inhigh grade squamous intraepithelial lesion in National Hospital of Obstetrics and Gynecology. Materials and Method: Cross- sectional descriptive research conducted on 92 women who were diagnosed with high grade squamous intraepithelial lesion. The research time frame was from June 2020 to October 2020 at National Hospital


 


 


                                                                                                                                                           



of Obstetrics and Gynecology. Results and conclusions: The mean age was 38.4± 9.6. The positive p16 staining rates of CIN 2 and CIN 3 lesions were 78.6% and 98.0%, respectively. Various levels of p53 expressions were detected in 59.5% of CIN 2 cases and 36.0% of CIN 3 cases, the difference was statistically significant with p<0.05

Article Details

Keywords

High grade squamous intraepithelial lesion, p16, p53

References

1. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet Lond Engl. 2007;370(9590): 890-907. doi: 10.1016/ S0140-6736(07)61416-0
2. Galgano MT, Castle PE, Atkins KA, Brix WK, Nassau SR, Stoler MH. Using Biomarkers as Objective Standards in the Diagnosis of Cervical Biopsies. Am J Surg Pathol. 2010;34(8):1077-

1087. doi:10.1097/PAS.0b013e3181e8b2c4
3. Kishore V, Patil AG. Expression of p16INK4A Protein in Cervical Intraepithelial Neoplasia and Invasive Carcinoma of Uterine Cervix. J Clin Diagn Res JCDR. 2017;11(9): EC17-EC20. doi: 10.7860/ JCDR/2017/29394.10644
4. Grace VMB, Shalini JV, lekha TTS, Devaraj SN, Devaraj H. Co-overexpression of p53 and bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix. Gynecol Oncol. 2003;91(1): 51- 58. doi: 10.1016/ s0090-8258(03) 00439-6
5. Lê Quang Vinh, Đàm Thị Quỳnh Liên, Lưu Thị Hồng. Tình trạng nhiễm HPV nguy cơ cao ở những phụ nữ có tổn thương tân sản nội biểu mô và ung thư cổ tử cung. Tạp Chí Phụ Sản. 2017;15(2):125-129.
6. Izadi-Mood N, Asadi K, Shojaei H, et al. Potential diagnostic value of P16 expression in premalignant and malignant cervical lesions. J Res Med Sci Off J Isfahan Univ Med Sci. 2012;17(5):428-433.
7. Lee S, Kim H, Kim H, Kim C, Kim I. The Utility of p16INK4a and Ki-67 as a Conjunctive Tool in Uterine Cervical Lesions. Korean J Pathol. 2012;46(3): 253-260. doi: 10.4132/ KoreanJ Pathol.2012.46.3.253
8. Ghosh D, Roy AK, Murmu N, Mandal S, Roy
A. Risk Categorization with Different Grades of Cervical Pre-Neoplastic Lesions - High Risk HPV Associations and Expression of p53 and RARβ. Asian Pac J Cancer Prev APJCP. 2019;20(2):549- 555. doi:10.31557/APJCP.2019.20.2.549
9. Silva D, da Silveira Gonçalves de Oliveira A, Cobucci R, Mendonça R, Lima P, Cavalcanti Jr G. Immunohistochemical expression of p16, Ki-
67 and p53 in cervical lesions - A systematic review. Pathol - Res Pract. 2017;213. doi:10.1016/j.prp.2017.03.003