U MÔ ĐỆM ĐƯỜNG TIÊU HÓA GIAI ĐOẠN DI CĂN Ở PHỤ NỮ CÓ THAI: BÁO CÁO MỘT TRƯỜNG HỢP HIẾM GẶP

Abstract

Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, which account for approximately 1 to 3 percent of gastrointestinal cancer. The development of GISTs due to mutations in the KIT gene accounts for 78 to 88 percent. The most common sites are in the stomach (40 to 60 percent), small intestine (20 to 30 percent), and other sites. The diagnosis of GISTs is using histopathology and CD117 positive on immunohistochemistry (IHC). Complete resection is the mainstay therapy and adjuvant imatinib therapy increases overall survival and decreases recurrence rate. The increasing incidence of this tumor and its successful treatment has given rise to issues of fertility and childbearing in patients affected at a young age. Although contraception advice and termination of early pregnancy have been the standard practice in patients on such therapy some patients still desire pregnancy. Clinical Presentation: We report our experience with a rare patient of metastatic GIST who had three times successful normal pregnancies, while on imatinib therapy at Vietnam National Cancer Hospital.