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EVALUATION OF THE RESULTS OF TREATMENT OF HIGH-GRADE CERVICAL INTRAEPITHELIAL NEOPLASIA (CIN) LESIONS TREATED THROUGH CONIZATION METHODS IN HUNG VUONG HOSPITAL IN 2018-2020
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Abstract
Background: Early screening through cytology and HPV screening can help identify precancerous cases to prevent their progression into invasive cervical cancer which can be treated by early interventions. These early interventions may include minimally invasive methods such as conization to remove the damaged tissue from the cervix. Objectives: 1. Determining the success rate of high-grade Cervical Intraepithelial Neoplasia (CIN) lesions treated through conization methods. 2. Identifying factors associated with treatment outcomes in conization for high-grade Cervical Intraepithelial Neoplasia (CIN) lesions. Methods: Cross-sectional study, sample size 220 cases undergoing initial conization in Hung Vuong hospital from 2018 to 2022.Results: The success rate of treating high-grade Cervical Intraepithelial Neoplasia (CIN) lesions through conization after 30 months is 87.7% (95% CI: 83.36-92.1%). The failure rate is 12.3%. Factors associated with conization treatment outcomes for CIN lesions: Age ≥ 38 years increases the risk of treatment failure with an odds ratio (OR) of 1.32 (95% CI: 1.22-3.95). This difference is statistically significant with p=0.012 < 0.05. Postmenopausal status increases the risk of treatment failure with an odds ratio (OR) of 1.18 (95% CI: 1.07-3.7). This difference is statistically significant with p=0.004 < 0.05. HPV infection post-conization significantly raises the risk of treatment failure by 5.8 times compared to HPV-negative cases, with an odds ratio (OR) of 5.8 (95% CI: 3.69-8.27). This difference is statistically significant with p < 0.001 < 0.05. Conclusion: Treatment of high-grade cervical lesions using the loop electrosurgical excision procedure (LEEP) or normal knife conization is associated with a high success rate. Advanced age, postmenopausal status, and post-conization HPV infection are identified as factors that increase the risk of treatment failure for conization procedures
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Keywords
Cervical cancer, Conization methods, CIN
References
2. Đỗ Thi Lệ Chi (2009), "Điều trị các tổn thương tân sinh trong biểu mô cổ tử cung độ II và III bằng phương pháp khoét chóp sử dụng vòng cắt đốt điện", (Bệnh viện Từ Dũ).
3. Phan Thị Nga (2007), Hiệu quả khoét chóp bằng vòng điện các tổn thương tân sinh trong biểu mô cổ tử cung.
4. Cao Ngọc Thành Hoàng Việt, Trần Thị Kim Anh (2015), "Đánh giá kết quả điều trị các tổn thương tiền ung thư tại Bệnh viện Trương Ương Huế", Tạp chí Phụ Sản. Tập 13 (Hội Phụ Sản Việt Nam), tr. 99-102.
5. Kreimer AR, Schiffman M et al Katki HA, (2007), "Viral determinants of human papillomavirus persistence following loop eclectrical excision procedure treatement for cervical intraepithelial neoplasia grade 2 or 3 ", Cancer Epidemiol Biomarker Prev. 16, tr. 11-16.
6. K Nagai N, Oshita T Mukai and et al (2004), "Human papillomavirus DNA status after loop excision for cervical intraepithelial neoplasia grade III - a prospective study", Int J Mol Med. 13, tr. 589-593.
7. Nam K, Chung S, Kim J, et al (2009), "Factors associated with HPV persistence after conization in patients with negative margins", J Gynecol Oncol. 20, tr. 91-95.
8. Ribadone, Naoko Kajitani and Stefan Schwartz (2020), "Role of Viral Ribonucleoproteins in Human Papillomavirus Type 16 Gene Expression", Arch Gynecol Obstet 282, tr. 193-197.
9. Yung-Taek Ouh, Hyun Woo Cho (2020), Risk factors for type specific persistence of high risk human papillomavirus and residual/recurrent cervical intraepithelial neoplasia after surgical treatment, Korean Society Obstetric & Gynecology Science.