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Ngày xuất bản:
11/05/2024
Số lượt xem tóm tắt: 101
Số lượt xem PDF: 60
Số lượt xem PDF: 60
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Trích dẫn bài báo
Tran, K. L. ., Nguyen , T. A. L., & Ngo Thi, Q.-M. (2024). CYTOTOXIC ACTIVITY OF FRACTIONS AND COMPOUNDS FROM PEPEROMIA PELLUCIDA. Tạp Chí Y học Việt Nam, 538(1). https://doi.org/10.51298/vmj.v538i1.9541
CYTOTOXIC ACTIVITY OF FRACTIONS AND COMPOUNDS FROM PEPEROMIA PELLUCIDA
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Tóm tắt
Peperomia pellucida is a widely distributed herb and commonly used in folk medicine for the treatment of various disorders. The present study reported the isolation, elucidation of compounds from the whole plant and their cytotoxic activities on Hep G2 (HB - 8065TM, hepatocellular carcinoma), A549 (CCL-185™, pulmonary adenocarcinoma), and MCF-7 (HTB - 22TM, breast cancer) cell lines. As a result, velutin exhibited the most significant cytotoxicity against Hep G2, A549, and MCF-7 cell lines with IC50 values of 34.00, 30.85, and 41.33 μg/mL, respectively.
Chi tiết bài viết
Từ khóa
Peperomia pellucida, Velutin, Flavonoid, Flavone, Cytotoxicity
Tài liệu tham khảo
1. Ho, K.L., et al., Peperomia pellucida (L.) Kunth and eye diseases: A review on phytochemistry, pharmacology and toxicology. Journal of Integrative Medicine (2022), 20(4): p. 292-304.
2. Wei, L.S., et al., Characterization of anticancer, antimicrobial, antioxidant properties and chemical compositions of Peperomia pellucida leaf extract. Acta Med Iran (2011), 49(10): p. 670-4.
3. Lin, M., et al., Peperomin E Induces Apoptosis and Cytoprotective Autophagy in Human Prostate Cancer DU145 Cells In Vitro and In Vivo. Planta Med (2021), 87(08): p. 620-630.
4. Ngo, Q.-M.T., et al., Carotane sesquiterpenes from Peperomia pellucida and their anti-infective activities. Natural Product Research (2023).
5. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods (1983), 65(1): p. 55-63.
6. Santoso, B.B., et al., Two Antibacterial Compounds: Velutin and 4- (Hydroxy (Oxiran-2-yl)Methyl)-2-Methoxyphenol from the Stem Bark of Drimys arfakensis Gibbs. KnE Life Sciences (2017), 3: p. 51-62.
7. Kang, J., et al., Flavonoids from acai (Euterpe oleracea Mart.) pulp and their antioxidant and anti-inflammatory activities. Food Chemistry (2011), 128(1): p. 152-157.
8. Zahir, A., et al., DNA topoisomerase I inhibitors: cytotoxic flavones from Lethedon tannaensis. J Nat Prod (1996), 59(7): p. 701-3.
2. Wei, L.S., et al., Characterization of anticancer, antimicrobial, antioxidant properties and chemical compositions of Peperomia pellucida leaf extract. Acta Med Iran (2011), 49(10): p. 670-4.
3. Lin, M., et al., Peperomin E Induces Apoptosis and Cytoprotective Autophagy in Human Prostate Cancer DU145 Cells In Vitro and In Vivo. Planta Med (2021), 87(08): p. 620-630.
4. Ngo, Q.-M.T., et al., Carotane sesquiterpenes from Peperomia pellucida and their anti-infective activities. Natural Product Research (2023).
5. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods (1983), 65(1): p. 55-63.
6. Santoso, B.B., et al., Two Antibacterial Compounds: Velutin and 4- (Hydroxy (Oxiran-2-yl)Methyl)-2-Methoxyphenol from the Stem Bark of Drimys arfakensis Gibbs. KnE Life Sciences (2017), 3: p. 51-62.
7. Kang, J., et al., Flavonoids from acai (Euterpe oleracea Mart.) pulp and their antioxidant and anti-inflammatory activities. Food Chemistry (2011), 128(1): p. 152-157.
8. Zahir, A., et al., DNA topoisomerase I inhibitors: cytotoxic flavones from Lethedon tannaensis. J Nat Prod (1996), 59(7): p. 701-3.