CLINICAL CHARACTERISTICS AND OUTCOMES AMONG ADULT PATIENTS WITH MEASLES AT HOSPITAL FOR TROPICAL DISEASES

Vo Trieu Ly1,, Bui Thi Nhat Hanh2, Nguyen Hoang Phi1, Tran Dang Khoa1, Vuong Minh Nhut1, Vu Thi Hieu3
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 Hopistal for Tropical Diseases
3 Pham Ngoc Thach Hospital

Nội dung chính của bài viết

Tóm tắt

Introduction: Measles is an acute infectious disease which occurs in children and adults who are not immune to measles. However, adult patients with measles often have more severe symptoms than children. Objectives: Description of the clinical and subclinical features, complications, and some related factors to complications of adult patients with measles. Methods: A cross-sectional study was conducted on patients aged ≥ 16 years with clinical symptoms suspected of measles and positive test result of serological immunoglobulin M for measles. Results: From October 2018 to May 2020, 294 patients meeting the inclusion criteria were enrolled. The average age was 29 ± 6. The sex ratio from male to female was 1:1.06. The most common clinical manifestations were high temperature, rash, and severe cough. About three-fourths of patients had elevated liver enzymes. Nearly one-third of adult patients with measles developed complications, including bronchitis (57.6%) and pneumonia (27.2%). Having a fever when the rash disappeared, a productive cough, and increased leukocytes were associated with the complication rate of measles (p < 0.001). Recommendation: Adult patients with measles had a high rate of complications, which were commonly bronchitis, pneumonia, and preterm birth in pregnant women. The proportion of complications in patients with persistent fever, productive cough, and increased leukocytes was higher than in the remaining groups.

Chi tiết bài viết

Tài liệu tham khảo

1. Giladi M. et al. "Measles in adults: a prospective study of 291 consecutive cases", Br Med J (Clin Res Ed),1987, 295(6609), pp. 1314.
2. Mahamud A. et al. "Risk factors for measles mortality among hospitalized Somali refugees displaced by famine, Kenya, 2011", Clin Infect Dis, 2013, 57(8), pp. 160-166.
3. Song Joon Young et al. "Epidemiologic and Clinical Features of Adult Patients with Measles During 2000 Epidemic", Korean Journal of Infectious Diseases, 2001, 33(6), pp. 443-447.
4. Sunnetcioglu M. et al. "Clinical and laboratory features of adult measles cases detected in Van, Turkey", J Pak Med Assoc, 2015, 65(3), pp. 273-276.
5. Yasunaga H. et al. "Measles-related hospitalizations and complications in Japan, 2007-2008", Intern Med, 2010, 49(18), pp. 1965-1970.
6. Cao Ngọc Nga, Nguyễn Hoài Phong và Đỗ Anh Tuấn, "Đặc điểm bệnh sởi trên bệnh nhân người lớn tại Bệnh viện Bệnh Nhiệt Đới", Tạp chí Y học TP.HCM, 2011, 15, tr. 522-529.
7. Nguyễn Văn Mẩn và Liên Huỳnh Phương, "Bước đầu nghiên cứu công nghệ sản xuất vắc-xin sởi tại Việt Nam qui mô phòng thí nghiệm", Trung tâm khoa học sản xuất vắc-xin sabin, 2002, tr. 10.
8. Trần Đăng Khoa, "Bệnh sởi", Bệnh truyền nhiễm, Nhà xuất bản Y học, 2020, tr. 260-276.